Biorelevant In Vitro Skin Permeation Testing and In Vivo Pharmacokinetic Characterization of Lidocaine from a Nonaqueous Drug-in-Matrix Topical System

Recently, lidocaine topical systems utilizing nonaqueous matrices have been developed and provide efficient lidocaine delivery through the skin, such that lower concentrations of drug provide equivalent or greater drug delivery than drug-in-matrix hydrogel lidocaine patches. This study characterizes...

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Detalles Bibliográficos
Autores principales: Greuber, Emileigh, Vought, Kip, Patel, Kalpana, Suzuki, Hiroaki, Usuda, Kazuhiro, Shiramizu, Akira, Koplowitz, Luana Pesco, Koplowitz, Barry, Maibach, Howard I., Lissin, Dmitri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360843/
https://www.ncbi.nlm.nih.gov/pubmed/34386908
http://dx.doi.org/10.1208/s12249-021-02101-y

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