The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases

Magnesium is an essential trace metal and a necessary factor for multiple biochemical functions in humans. Its role in biology is fundamental in over 600 enzymatic reactions implicated in protein synthesis, mitochondrial functions, neuromuscular activity, bone formation, and immune system competence...

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Autores principales: Fanni, Daniela, Gerosa, C., Nurchi, V. M., Manchia, M., Saba, L., Coghe, F., Crisponi, G., Gibo, Y., Van Eyken, P., Fanos, V., Faa, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360883/
https://www.ncbi.nlm.nih.gov/pubmed/33319331
http://dx.doi.org/10.1007/s12011-020-02513-0
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author Fanni, Daniela
Gerosa, C.
Nurchi, V. M.
Manchia, M.
Saba, L.
Coghe, F.
Crisponi, G.
Gibo, Y.
Van Eyken, P.
Fanos, V.
Faa, G.
author_facet Fanni, Daniela
Gerosa, C.
Nurchi, V. M.
Manchia, M.
Saba, L.
Coghe, F.
Crisponi, G.
Gibo, Y.
Van Eyken, P.
Fanos, V.
Faa, G.
author_sort Fanni, Daniela
collection PubMed
description Magnesium is an essential trace metal and a necessary factor for multiple biochemical functions in humans. Its role in biology is fundamental in over 600 enzymatic reactions implicated in protein synthesis, mitochondrial functions, neuromuscular activity, bone formation, and immune system competence. Magnesium status is relevant in fetal development during gestation and in the newborn growth during the perinatal period. Moreover, magnesium is able to influence fetal programming and disease presentation in childhood or adulthood. The aim of this review is to focus on this metal homeostasis, analyzing its normal values, the causes of hypomagnesemia, the interaction with drugs and other conditions, and the diseases associated with magnesium value alteration during pregnancy, in order to study its role in fetal programming of adult diseases. The data here reported clearly indicated the existence of a connection between magnesium status and human pathology starting from intrauterine life and extending into childhood and adulthood.
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spelling pubmed-83608832021-08-30 The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases Fanni, Daniela Gerosa, C. Nurchi, V. M. Manchia, M. Saba, L. Coghe, F. Crisponi, G. Gibo, Y. Van Eyken, P. Fanos, V. Faa, G. Biol Trace Elem Res Article Magnesium is an essential trace metal and a necessary factor for multiple biochemical functions in humans. Its role in biology is fundamental in over 600 enzymatic reactions implicated in protein synthesis, mitochondrial functions, neuromuscular activity, bone formation, and immune system competence. Magnesium status is relevant in fetal development during gestation and in the newborn growth during the perinatal period. Moreover, magnesium is able to influence fetal programming and disease presentation in childhood or adulthood. The aim of this review is to focus on this metal homeostasis, analyzing its normal values, the causes of hypomagnesemia, the interaction with drugs and other conditions, and the diseases associated with magnesium value alteration during pregnancy, in order to study its role in fetal programming of adult diseases. The data here reported clearly indicated the existence of a connection between magnesium status and human pathology starting from intrauterine life and extending into childhood and adulthood. Springer US 2020-12-14 2021 /pmc/articles/PMC8360883/ /pubmed/33319331 http://dx.doi.org/10.1007/s12011-020-02513-0 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Fanni, Daniela
Gerosa, C.
Nurchi, V. M.
Manchia, M.
Saba, L.
Coghe, F.
Crisponi, G.
Gibo, Y.
Van Eyken, P.
Fanos, V.
Faa, G.
The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases
title The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases
title_full The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases
title_fullStr The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases
title_full_unstemmed The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases
title_short The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases
title_sort role of magnesium in pregnancy and in fetal programming of adult diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360883/
https://www.ncbi.nlm.nih.gov/pubmed/33319331
http://dx.doi.org/10.1007/s12011-020-02513-0
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