Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma

A postprandial increase of translation mediated by eukaryotic Initiation Factor 6 (eIF6) occurs in the liver. Its contribution to steatosis and disease is unknown. In this study we address whether eIF6-driven translation contributes to disease progression. eIF6 levels increase throughout the progres...

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Detalles Bibliográficos
Autores principales: Scagliola, Alessandra, Miluzio, Annarita, Ventura, Gabriele, Oliveto, Stefania, Cordiglieri, Chiara, Manfrini, Nicola, Cirino, Delia, Ricciardi, Sara, Valenti, Luca, Baselli, Guido, D’Ambrosio, Roberta, Maggioni, Marco, Brina, Daniela, Bresciani, Alberto, Biffo, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361022/
https://www.ncbi.nlm.nih.gov/pubmed/34385447
http://dx.doi.org/10.1038/s41467-021-25195-1

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