Liquid biopsy uncovers distinct patterns of DNA methylation and copy number changes in NSCLC patients with different EGFR-TKI resistant mutations

Targeted therapy with tyrosine kinase inhibitors (TKI) provides survival benefits to a majority of patients with non-small cell lung cancer (NSCLC). However, resistance to TKI almost always develops after treatment. Although genetic and epigenetic alterations have each been shown to drive resistance...

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Detalles Bibliográficos
Autores principales: Nguyen, Hoai-Nghia, Cao, Ngoc-Phuong Thi, Van Nguyen, Thien-Chi, Le, Khang Nguyen Duy, Nguyen, Dat Thanh, Nguyen, Quynh-Tho Thi, Nguyen, Thai-Hoa Thi, Van Nguyen, Chu, Le, Ha Thu, Nguyen, Mai-Lan Thi, Nguyen, Trieu Vu, Tran, Vu Uyen, Luong, Bac An, Le, Linh Gia Hoang, Ho, Quoc Chuong, Pham, Hong-Anh Thi, Vo, Binh Thanh, Nguyen, Luan Thanh, Dang, Anh-Thu Huynh, Nguyen, Sinh Duy, Do, Duc Minh, Do, Thanh-Thuy Thi, Hoang, Anh Vu, Dinh, Kiet Truong, Phan, Minh-Duy, Giang, Hoa, Tran, Le Son
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361064/
https://www.ncbi.nlm.nih.gov/pubmed/34385540
http://dx.doi.org/10.1038/s41598-021-95985-6

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