Cargando…

Incident stroke in patients with Alzheimer’s disease: systematic review and meta-analysis

Vascular mechanisms are increasingly recognized in the pathophysiology of Alzheimer’s disease (AD), but less is known about the occurrence of stroke in AD patients. We aimed to quantify the risk of stroke in patients with AD and compare the incidence rates (IR) of stroke in individuals without AD. S...

Descripción completa

Detalles Bibliográficos
Autores principales: Pinho, João, Quintas-Neves, Miguel, Dogan, Imis, Reetz, Kathrin, Reich, Arno, Costa, Ana Sofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361108/
https://www.ncbi.nlm.nih.gov/pubmed/34385535
http://dx.doi.org/10.1038/s41598-021-95821-x
_version_ 1783737890404040704
author Pinho, João
Quintas-Neves, Miguel
Dogan, Imis
Reetz, Kathrin
Reich, Arno
Costa, Ana Sofia
author_facet Pinho, João
Quintas-Neves, Miguel
Dogan, Imis
Reetz, Kathrin
Reich, Arno
Costa, Ana Sofia
author_sort Pinho, João
collection PubMed
description Vascular mechanisms are increasingly recognized in the pathophysiology of Alzheimer’s disease (AD), but less is known about the occurrence of stroke in AD patients. We aimed to quantify the risk of stroke in patients with AD and compare the incidence rates (IR) of stroke in individuals without AD. Systematic search of Embase and MEDLINE between 1970 and 2020. Inclusion criteria: reports with ≥ 50 patients with non-familial AD, which reported the occurrence of stroke (all types) and/or ischemic stroke and/or intracerebral hemorrhage (ICH) during follow-up. Meta-analyses of pooled data using random-effects model were performed. IR were calculated for each study. Incidence rate ratios (IRR) were calculated for studies presenting a control-group without AD. Among 5109 retrieved studies, 29 (0.6%) fulfilled the inclusion criteria, reporting a total of 61,824 AD patients. In AD patients the IR were 15.4/1000 person-years for stroke (all types), 13.0/1000 person-years for ischemic stroke and 3.4/1000 person-years for ICH. When compared to controls without AD, incidence rate for ICH in AD patients was significantly higher (IRR = 1.67, 95%CI 1.43–1.96), but similar for ischemic stroke. Incident stroke is not a rare event in AD population. AD is associated with an increased risk of intracerebral hemorrhage which warrants further clarification.
format Online
Article
Text
id pubmed-8361108
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-83611082021-08-17 Incident stroke in patients with Alzheimer’s disease: systematic review and meta-analysis Pinho, João Quintas-Neves, Miguel Dogan, Imis Reetz, Kathrin Reich, Arno Costa, Ana Sofia Sci Rep Article Vascular mechanisms are increasingly recognized in the pathophysiology of Alzheimer’s disease (AD), but less is known about the occurrence of stroke in AD patients. We aimed to quantify the risk of stroke in patients with AD and compare the incidence rates (IR) of stroke in individuals without AD. Systematic search of Embase and MEDLINE between 1970 and 2020. Inclusion criteria: reports with ≥ 50 patients with non-familial AD, which reported the occurrence of stroke (all types) and/or ischemic stroke and/or intracerebral hemorrhage (ICH) during follow-up. Meta-analyses of pooled data using random-effects model were performed. IR were calculated for each study. Incidence rate ratios (IRR) were calculated for studies presenting a control-group without AD. Among 5109 retrieved studies, 29 (0.6%) fulfilled the inclusion criteria, reporting a total of 61,824 AD patients. In AD patients the IR were 15.4/1000 person-years for stroke (all types), 13.0/1000 person-years for ischemic stroke and 3.4/1000 person-years for ICH. When compared to controls without AD, incidence rate for ICH in AD patients was significantly higher (IRR = 1.67, 95%CI 1.43–1.96), but similar for ischemic stroke. Incident stroke is not a rare event in AD population. AD is associated with an increased risk of intracerebral hemorrhage which warrants further clarification. Nature Publishing Group UK 2021-08-12 /pmc/articles/PMC8361108/ /pubmed/34385535 http://dx.doi.org/10.1038/s41598-021-95821-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Pinho, João
Quintas-Neves, Miguel
Dogan, Imis
Reetz, Kathrin
Reich, Arno
Costa, Ana Sofia
Incident stroke in patients with Alzheimer’s disease: systematic review and meta-analysis
title Incident stroke in patients with Alzheimer’s disease: systematic review and meta-analysis
title_full Incident stroke in patients with Alzheimer’s disease: systematic review and meta-analysis
title_fullStr Incident stroke in patients with Alzheimer’s disease: systematic review and meta-analysis
title_full_unstemmed Incident stroke in patients with Alzheimer’s disease: systematic review and meta-analysis
title_short Incident stroke in patients with Alzheimer’s disease: systematic review and meta-analysis
title_sort incident stroke in patients with alzheimer’s disease: systematic review and meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361108/
https://www.ncbi.nlm.nih.gov/pubmed/34385535
http://dx.doi.org/10.1038/s41598-021-95821-x
work_keys_str_mv AT pinhojoao incidentstrokeinpatientswithalzheimersdiseasesystematicreviewandmetaanalysis
AT quintasnevesmiguel incidentstrokeinpatientswithalzheimersdiseasesystematicreviewandmetaanalysis
AT doganimis incidentstrokeinpatientswithalzheimersdiseasesystematicreviewandmetaanalysis
AT reetzkathrin incidentstrokeinpatientswithalzheimersdiseasesystematicreviewandmetaanalysis
AT reicharno incidentstrokeinpatientswithalzheimersdiseasesystematicreviewandmetaanalysis
AT costaanasofia incidentstrokeinpatientswithalzheimersdiseasesystematicreviewandmetaanalysis