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Acquired olfactory loss alters functional connectivity and morphology

Removing function from a developed and functional sensory system is known to alter both cerebral morphology and functional connections. To date, a majority of studies assessing sensory-dependent plasticity have focused on effects from either early onset or long-term sensory loss and little is known...

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Autores principales: Iravani, Behzad, Peter, Moa G., Arshamian, Artin, Olsson, Mats J., Hummel, Thomas, Kitzler, Hagen H., Lundström, Johan N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361122/
https://www.ncbi.nlm.nih.gov/pubmed/34385571
http://dx.doi.org/10.1038/s41598-021-95968-7
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author Iravani, Behzad
Peter, Moa G.
Arshamian, Artin
Olsson, Mats J.
Hummel, Thomas
Kitzler, Hagen H.
Lundström, Johan N.
author_facet Iravani, Behzad
Peter, Moa G.
Arshamian, Artin
Olsson, Mats J.
Hummel, Thomas
Kitzler, Hagen H.
Lundström, Johan N.
author_sort Iravani, Behzad
collection PubMed
description Removing function from a developed and functional sensory system is known to alter both cerebral morphology and functional connections. To date, a majority of studies assessing sensory-dependent plasticity have focused on effects from either early onset or long-term sensory loss and little is known how the recent sensory loss affects the human brain. With the aim of determining how recent sensory loss affects cerebral morphology and functional connectivity, we assessed differences between individuals with acquired olfactory loss (duration 7–36 months) and matched healthy controls in their grey matter volume, using multivariate pattern analyses, and functional connectivity, using dynamic connectivity analyses, within and from the olfactory cortex. Our results demonstrate that acquired olfactory loss is associated with altered grey matter volume in, among others, posterior piriform cortex, a core olfactory processing area, as well as the inferior frontal gyrus and angular gyrus. In addition, compared to controls, individuals with acquired anosmia displayed significantly stronger dynamic functional connectivity from the posterior piriform cortex to, among others, the angular gyrus, a known multisensory integration area. When assessing differences in dynamic functional connectivity from the angular gyrus, individuals with acquired anosmia had stronger connectivity from the angular gyrus to areas primary responsible for basic visual processing. These results demonstrate that recently acquired sensory loss is associated with both changed cerebral morphology within core olfactory areas and increase dynamic functional connectivity from olfactory cortex to cerebral areas processing multisensory integration.
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spelling pubmed-83611222021-08-17 Acquired olfactory loss alters functional connectivity and morphology Iravani, Behzad Peter, Moa G. Arshamian, Artin Olsson, Mats J. Hummel, Thomas Kitzler, Hagen H. Lundström, Johan N. Sci Rep Article Removing function from a developed and functional sensory system is known to alter both cerebral morphology and functional connections. To date, a majority of studies assessing sensory-dependent plasticity have focused on effects from either early onset or long-term sensory loss and little is known how the recent sensory loss affects the human brain. With the aim of determining how recent sensory loss affects cerebral morphology and functional connectivity, we assessed differences between individuals with acquired olfactory loss (duration 7–36 months) and matched healthy controls in their grey matter volume, using multivariate pattern analyses, and functional connectivity, using dynamic connectivity analyses, within and from the olfactory cortex. Our results demonstrate that acquired olfactory loss is associated with altered grey matter volume in, among others, posterior piriform cortex, a core olfactory processing area, as well as the inferior frontal gyrus and angular gyrus. In addition, compared to controls, individuals with acquired anosmia displayed significantly stronger dynamic functional connectivity from the posterior piriform cortex to, among others, the angular gyrus, a known multisensory integration area. When assessing differences in dynamic functional connectivity from the angular gyrus, individuals with acquired anosmia had stronger connectivity from the angular gyrus to areas primary responsible for basic visual processing. These results demonstrate that recently acquired sensory loss is associated with both changed cerebral morphology within core olfactory areas and increase dynamic functional connectivity from olfactory cortex to cerebral areas processing multisensory integration. Nature Publishing Group UK 2021-08-12 /pmc/articles/PMC8361122/ /pubmed/34385571 http://dx.doi.org/10.1038/s41598-021-95968-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Iravani, Behzad
Peter, Moa G.
Arshamian, Artin
Olsson, Mats J.
Hummel, Thomas
Kitzler, Hagen H.
Lundström, Johan N.
Acquired olfactory loss alters functional connectivity and morphology
title Acquired olfactory loss alters functional connectivity and morphology
title_full Acquired olfactory loss alters functional connectivity and morphology
title_fullStr Acquired olfactory loss alters functional connectivity and morphology
title_full_unstemmed Acquired olfactory loss alters functional connectivity and morphology
title_short Acquired olfactory loss alters functional connectivity and morphology
title_sort acquired olfactory loss alters functional connectivity and morphology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361122/
https://www.ncbi.nlm.nih.gov/pubmed/34385571
http://dx.doi.org/10.1038/s41598-021-95968-7
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