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Polarized X-ray scattering measures molecular orientation in polymer-grafted nanoparticles

Polymer chains are attached to nanoparticle surfaces for many purposes, including altering solubility, influencing aggregation, dispersion, and even tailoring immune responses in drug delivery. The most unique structural motif of polymer-grafted nanoparticles (PGNs) is the high-density region in the...

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Autores principales: Mukherjee, Subhrangsu, Streit, Jason K., Gann, Eliot, Saurabh, Kumar, Sunday, Daniel F., Krishnamurthy, Adarsh, Ganapathysubramanian, Baskar, Richter, Lee J., Vaia, Richard A., DeLongchamp, Dean M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361200/
https://www.ncbi.nlm.nih.gov/pubmed/34385430
http://dx.doi.org/10.1038/s41467-021-25176-4
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author Mukherjee, Subhrangsu
Streit, Jason K.
Gann, Eliot
Saurabh, Kumar
Sunday, Daniel F.
Krishnamurthy, Adarsh
Ganapathysubramanian, Baskar
Richter, Lee J.
Vaia, Richard A.
DeLongchamp, Dean M.
author_facet Mukherjee, Subhrangsu
Streit, Jason K.
Gann, Eliot
Saurabh, Kumar
Sunday, Daniel F.
Krishnamurthy, Adarsh
Ganapathysubramanian, Baskar
Richter, Lee J.
Vaia, Richard A.
DeLongchamp, Dean M.
author_sort Mukherjee, Subhrangsu
collection PubMed
description Polymer chains are attached to nanoparticle surfaces for many purposes, including altering solubility, influencing aggregation, dispersion, and even tailoring immune responses in drug delivery. The most unique structural motif of polymer-grafted nanoparticles (PGNs) is the high-density region in the corona where polymer chains are stretched under significant confinement, but orientation of these chains has never been measured because conventional nanoscale-resolved measurements lack sensitivity to polymer orientation in amorphous regions. Here, we directly measure local chain orientation in polystyrene grafted gold nanoparticles using polarized resonant soft X-ray scattering (P-RSoXS). Using a computational scattering pattern simulation approach, we measure the thickness of the anisotropic region of the corona and extent of chain orientation within it. These results demonstrate the power of P-RSoXS to discover and quantify orientational aspects of structure in amorphous soft materials and provide a framework for applying this emerging technique to more complex, chemically heterogeneous systems in the future.
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spelling pubmed-83612002021-08-19 Polarized X-ray scattering measures molecular orientation in polymer-grafted nanoparticles Mukherjee, Subhrangsu Streit, Jason K. Gann, Eliot Saurabh, Kumar Sunday, Daniel F. Krishnamurthy, Adarsh Ganapathysubramanian, Baskar Richter, Lee J. Vaia, Richard A. DeLongchamp, Dean M. Nat Commun Article Polymer chains are attached to nanoparticle surfaces for many purposes, including altering solubility, influencing aggregation, dispersion, and even tailoring immune responses in drug delivery. The most unique structural motif of polymer-grafted nanoparticles (PGNs) is the high-density region in the corona where polymer chains are stretched under significant confinement, but orientation of these chains has never been measured because conventional nanoscale-resolved measurements lack sensitivity to polymer orientation in amorphous regions. Here, we directly measure local chain orientation in polystyrene grafted gold nanoparticles using polarized resonant soft X-ray scattering (P-RSoXS). Using a computational scattering pattern simulation approach, we measure the thickness of the anisotropic region of the corona and extent of chain orientation within it. These results demonstrate the power of P-RSoXS to discover and quantify orientational aspects of structure in amorphous soft materials and provide a framework for applying this emerging technique to more complex, chemically heterogeneous systems in the future. Nature Publishing Group UK 2021-08-12 /pmc/articles/PMC8361200/ /pubmed/34385430 http://dx.doi.org/10.1038/s41467-021-25176-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Mukherjee, Subhrangsu
Streit, Jason K.
Gann, Eliot
Saurabh, Kumar
Sunday, Daniel F.
Krishnamurthy, Adarsh
Ganapathysubramanian, Baskar
Richter, Lee J.
Vaia, Richard A.
DeLongchamp, Dean M.
Polarized X-ray scattering measures molecular orientation in polymer-grafted nanoparticles
title Polarized X-ray scattering measures molecular orientation in polymer-grafted nanoparticles
title_full Polarized X-ray scattering measures molecular orientation in polymer-grafted nanoparticles
title_fullStr Polarized X-ray scattering measures molecular orientation in polymer-grafted nanoparticles
title_full_unstemmed Polarized X-ray scattering measures molecular orientation in polymer-grafted nanoparticles
title_short Polarized X-ray scattering measures molecular orientation in polymer-grafted nanoparticles
title_sort polarized x-ray scattering measures molecular orientation in polymer-grafted nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361200/
https://www.ncbi.nlm.nih.gov/pubmed/34385430
http://dx.doi.org/10.1038/s41467-021-25176-4
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