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Dietary intake of tocopherols and risk of incident disabling dementia
Tocopherols, strong antioxidants, may be useful in preventing dementia, but the epidemiological evidence is insufficient. We performed a community-based follow-up study of Japanese, the Circulatory Risk in Community Study, involving 3739 people aged 40–64 years at baseline (1985–1999). Incident disa...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361201/ https://www.ncbi.nlm.nih.gov/pubmed/34385499 http://dx.doi.org/10.1038/s41598-021-95671-7 |
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author | Aoki, Shoko Yamagishi, Kazumasa Maruyama, Koutatsu Kishida, Rie Ikeda, Ai Umesawa, Mitsumasa Renzhe, Cui Kubota, Yasuhiko Hayama-Terada, Mina Shimizu, Yuji Muraki, Isao Imano, Hironori Sankai, Tomoko Okada, Takeo Kitamura, Akihiko Kiyama, Masahiko Iso, Hiroyasu |
author_facet | Aoki, Shoko Yamagishi, Kazumasa Maruyama, Koutatsu Kishida, Rie Ikeda, Ai Umesawa, Mitsumasa Renzhe, Cui Kubota, Yasuhiko Hayama-Terada, Mina Shimizu, Yuji Muraki, Isao Imano, Hironori Sankai, Tomoko Okada, Takeo Kitamura, Akihiko Kiyama, Masahiko Iso, Hiroyasu |
author_sort | Aoki, Shoko |
collection | PubMed |
description | Tocopherols, strong antioxidants, may be useful in preventing dementia, but the epidemiological evidence is insufficient. We performed a community-based follow-up study of Japanese, the Circulatory Risk in Community Study, involving 3739 people aged 40–64 years at baseline (1985–1999). Incident disabling dementia was followed up from 1999 through 2020. For subtype analysis, we classified disabling dementia into that with and that without a history of stroke. Dietary intake of tocopherols (total, α, β, γ, and δ) were estimated using 24-h recall surveys. During a median follow-up of 19.7 years, 670 cases of disabling dementia developed. Total tocopherol intake was inversely associated with risk of disabling dementia with multivariable hazard ratios (95% confidence intervals) of 0.79 (0.63–1.00) for the highest versus lowest quartiles of total tocopherol intake (P for trend = 0.05). However, the association was strengthened when further adjusted for α-linolenic acid intake (Spearman correlation with total tocopherol intake = 0.93), with multivariable hazard ratios of 0.50 (0.34–0.74) (P for trend = 0.001) but was weakened and nonsignificant when further adjusted for linoleic acid intake (Spearman correlation with total tocopherol intake = 0.92), with multivariable hazard ratios of 0.69 (0.47–1.01) (P for trend = 0.05). Similar but nonsignificant inverse associations were observed for α-, γ-, and δ-tocopherols but not for β-tocopherol. These results were similar regardless of the presence of a history of stroke. Dietary tocopherol intake was inversely associated with risk of disabling dementia, but its independent effect was uncertain owing to a high intercorrelation of α-linolenic linoleic acids with total tocopherol intake. Even with such confounding, a diet high in tocopherols may help prevent the onset of dementia. |
format | Online Article Text |
id | pubmed-8361201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-83612012021-08-17 Dietary intake of tocopherols and risk of incident disabling dementia Aoki, Shoko Yamagishi, Kazumasa Maruyama, Koutatsu Kishida, Rie Ikeda, Ai Umesawa, Mitsumasa Renzhe, Cui Kubota, Yasuhiko Hayama-Terada, Mina Shimizu, Yuji Muraki, Isao Imano, Hironori Sankai, Tomoko Okada, Takeo Kitamura, Akihiko Kiyama, Masahiko Iso, Hiroyasu Sci Rep Article Tocopherols, strong antioxidants, may be useful in preventing dementia, but the epidemiological evidence is insufficient. We performed a community-based follow-up study of Japanese, the Circulatory Risk in Community Study, involving 3739 people aged 40–64 years at baseline (1985–1999). Incident disabling dementia was followed up from 1999 through 2020. For subtype analysis, we classified disabling dementia into that with and that without a history of stroke. Dietary intake of tocopherols (total, α, β, γ, and δ) were estimated using 24-h recall surveys. During a median follow-up of 19.7 years, 670 cases of disabling dementia developed. Total tocopherol intake was inversely associated with risk of disabling dementia with multivariable hazard ratios (95% confidence intervals) of 0.79 (0.63–1.00) for the highest versus lowest quartiles of total tocopherol intake (P for trend = 0.05). However, the association was strengthened when further adjusted for α-linolenic acid intake (Spearman correlation with total tocopherol intake = 0.93), with multivariable hazard ratios of 0.50 (0.34–0.74) (P for trend = 0.001) but was weakened and nonsignificant when further adjusted for linoleic acid intake (Spearman correlation with total tocopherol intake = 0.92), with multivariable hazard ratios of 0.69 (0.47–1.01) (P for trend = 0.05). Similar but nonsignificant inverse associations were observed for α-, γ-, and δ-tocopherols but not for β-tocopherol. These results were similar regardless of the presence of a history of stroke. Dietary tocopherol intake was inversely associated with risk of disabling dementia, but its independent effect was uncertain owing to a high intercorrelation of α-linolenic linoleic acids with total tocopherol intake. Even with such confounding, a diet high in tocopherols may help prevent the onset of dementia. Nature Publishing Group UK 2021-08-12 /pmc/articles/PMC8361201/ /pubmed/34385499 http://dx.doi.org/10.1038/s41598-021-95671-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Aoki, Shoko Yamagishi, Kazumasa Maruyama, Koutatsu Kishida, Rie Ikeda, Ai Umesawa, Mitsumasa Renzhe, Cui Kubota, Yasuhiko Hayama-Terada, Mina Shimizu, Yuji Muraki, Isao Imano, Hironori Sankai, Tomoko Okada, Takeo Kitamura, Akihiko Kiyama, Masahiko Iso, Hiroyasu Dietary intake of tocopherols and risk of incident disabling dementia |
title | Dietary intake of tocopherols and risk of incident disabling dementia |
title_full | Dietary intake of tocopherols and risk of incident disabling dementia |
title_fullStr | Dietary intake of tocopherols and risk of incident disabling dementia |
title_full_unstemmed | Dietary intake of tocopherols and risk of incident disabling dementia |
title_short | Dietary intake of tocopherols and risk of incident disabling dementia |
title_sort | dietary intake of tocopherols and risk of incident disabling dementia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361201/ https://www.ncbi.nlm.nih.gov/pubmed/34385499 http://dx.doi.org/10.1038/s41598-021-95671-7 |
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