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Shigella OspC3 suppresses murine cytosolic LPS sensing

Shigella flexneri, a cytosol-invasive gram-negative pathogen, deploys an array of type III-secreted effector proteins to evade host cell defenses. Caspase-11 and its human ortholog caspase-4 detect cytosolic lipopolysaccharide (LPS) and trigger gasdermin D-mediated pyroptosis to eliminate intra-cyto...

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Detalles Bibliográficos
Autores principales:	Oh, Changhoon, Verma, Ambika, Hafeez, Mohib, Hogland, Brandon, Aachoui, Youssef
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361271/ https://www.ncbi.nlm.nih.gov/pubmed/34409271 http://dx.doi.org/10.1016/j.isci.2021.102910

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