β-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs

OBJECTIVE: β-cell microRNA-21 (miR-21) is increased by islet inflammatory stress but it decreases glucose-stimulated insulin secretion (GSIS). Thus, we sought to define the effects of miR-21 on β-cell function using in vitro and in vivo systems. METHODS: We developed a tetracycline-on system of pre-...

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Detalles Bibliográficos
Autores principales: Ibrahim, Sara, Johnson, Macey, Stephens, Clarissa Hernandez, Xu, Jerry, Moore, Rachel, Mariani, Andrea, Contreras, Christopher, Syed, Farooq, Mirmira, Raghavendra G., Anderson, Ryan M., Sims, Emily K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361274/
https://www.ncbi.nlm.nih.gov/pubmed/34246804
http://dx.doi.org/10.1016/j.molmet.2021.101289

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