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Epstein-Barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement

PURPOSE: Post-transplant lymphoproliferative disorder (PTLD) represents a spectrum of disorders associated with Epstein Barr Virus infection in up to 80% of cases in the setting of pharmacologic immunosuppression following hematopoietic stem cell or solid organ transplantation. Ocular involvement is...

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Autores principales: Adam, Mainguy, Elise, Philippakis, Sutra Del Galy, Aurélien, Dinu, Stanescu-Segall, Ramin, Tadayoni, Bahram, Bodaghi, Sophie, Bonnin, Sara, Touhami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361285/
https://www.ncbi.nlm.nih.gov/pubmed/34409196
http://dx.doi.org/10.1016/j.ajoc.2021.101186
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author Adam, Mainguy
Elise, Philippakis
Sutra Del Galy, Aurélien
Dinu, Stanescu-Segall
Ramin, Tadayoni
Bahram, Bodaghi
Sophie, Bonnin
Sara, Touhami
author_facet Adam, Mainguy
Elise, Philippakis
Sutra Del Galy, Aurélien
Dinu, Stanescu-Segall
Ramin, Tadayoni
Bahram, Bodaghi
Sophie, Bonnin
Sara, Touhami
author_sort Adam, Mainguy
collection PubMed
description PURPOSE: Post-transplant lymphoproliferative disorder (PTLD) represents a spectrum of disorders associated with Epstein Barr Virus infection in up to 80% of cases in the setting of pharmacologic immunosuppression following hematopoietic stem cell or solid organ transplantation. Ocular involvement is a rare finding in PTLD. OBSERVATION: We report the case of a 38-year-old man who presented with unilateral retinal infiltrates as first manifestation of PTLD relapse. Diagnosis relied on the presence of EBV DNA in anterior chamber fluids and vitrectomy that showed the presence of a B cell clone. Systemic relapse of PTLD was detected 12 weeks after retinal findings. Treatment of ocular disease included systemic injections of rituximab and intravitreal injections of methotrexate, halting the extension of retinal infiltrates. CONCLUSION: Ocular involvement in PTLD is rare and needs to be acknowledged because it can precede a systemic relapse of the hematological condition.
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spelling pubmed-83612852021-08-17 Epstein-Barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement Adam, Mainguy Elise, Philippakis Sutra Del Galy, Aurélien Dinu, Stanescu-Segall Ramin, Tadayoni Bahram, Bodaghi Sophie, Bonnin Sara, Touhami Am J Ophthalmol Case Rep Case Report PURPOSE: Post-transplant lymphoproliferative disorder (PTLD) represents a spectrum of disorders associated with Epstein Barr Virus infection in up to 80% of cases in the setting of pharmacologic immunosuppression following hematopoietic stem cell or solid organ transplantation. Ocular involvement is a rare finding in PTLD. OBSERVATION: We report the case of a 38-year-old man who presented with unilateral retinal infiltrates as first manifestation of PTLD relapse. Diagnosis relied on the presence of EBV DNA in anterior chamber fluids and vitrectomy that showed the presence of a B cell clone. Systemic relapse of PTLD was detected 12 weeks after retinal findings. Treatment of ocular disease included systemic injections of rituximab and intravitreal injections of methotrexate, halting the extension of retinal infiltrates. CONCLUSION: Ocular involvement in PTLD is rare and needs to be acknowledged because it can precede a systemic relapse of the hematological condition. Elsevier 2021-08-02 /pmc/articles/PMC8361285/ /pubmed/34409196 http://dx.doi.org/10.1016/j.ajoc.2021.101186 Text en © 2021 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Adam, Mainguy
Elise, Philippakis
Sutra Del Galy, Aurélien
Dinu, Stanescu-Segall
Ramin, Tadayoni
Bahram, Bodaghi
Sophie, Bonnin
Sara, Touhami
Epstein-Barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement
title Epstein-Barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement
title_full Epstein-Barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement
title_fullStr Epstein-Barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement
title_full_unstemmed Epstein-Barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement
title_short Epstein-Barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement
title_sort epstein-barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361285/
https://www.ncbi.nlm.nih.gov/pubmed/34409196
http://dx.doi.org/10.1016/j.ajoc.2021.101186
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