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Epstein-Barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement
PURPOSE: Post-transplant lymphoproliferative disorder (PTLD) represents a spectrum of disorders associated with Epstein Barr Virus infection in up to 80% of cases in the setting of pharmacologic immunosuppression following hematopoietic stem cell or solid organ transplantation. Ocular involvement is...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361285/ https://www.ncbi.nlm.nih.gov/pubmed/34409196 http://dx.doi.org/10.1016/j.ajoc.2021.101186 |
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author | Adam, Mainguy Elise, Philippakis Sutra Del Galy, Aurélien Dinu, Stanescu-Segall Ramin, Tadayoni Bahram, Bodaghi Sophie, Bonnin Sara, Touhami |
author_facet | Adam, Mainguy Elise, Philippakis Sutra Del Galy, Aurélien Dinu, Stanescu-Segall Ramin, Tadayoni Bahram, Bodaghi Sophie, Bonnin Sara, Touhami |
author_sort | Adam, Mainguy |
collection | PubMed |
description | PURPOSE: Post-transplant lymphoproliferative disorder (PTLD) represents a spectrum of disorders associated with Epstein Barr Virus infection in up to 80% of cases in the setting of pharmacologic immunosuppression following hematopoietic stem cell or solid organ transplantation. Ocular involvement is a rare finding in PTLD. OBSERVATION: We report the case of a 38-year-old man who presented with unilateral retinal infiltrates as first manifestation of PTLD relapse. Diagnosis relied on the presence of EBV DNA in anterior chamber fluids and vitrectomy that showed the presence of a B cell clone. Systemic relapse of PTLD was detected 12 weeks after retinal findings. Treatment of ocular disease included systemic injections of rituximab and intravitreal injections of methotrexate, halting the extension of retinal infiltrates. CONCLUSION: Ocular involvement in PTLD is rare and needs to be acknowledged because it can precede a systemic relapse of the hematological condition. |
format | Online Article Text |
id | pubmed-8361285 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-83612852021-08-17 Epstein-Barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement Adam, Mainguy Elise, Philippakis Sutra Del Galy, Aurélien Dinu, Stanescu-Segall Ramin, Tadayoni Bahram, Bodaghi Sophie, Bonnin Sara, Touhami Am J Ophthalmol Case Rep Case Report PURPOSE: Post-transplant lymphoproliferative disorder (PTLD) represents a spectrum of disorders associated with Epstein Barr Virus infection in up to 80% of cases in the setting of pharmacologic immunosuppression following hematopoietic stem cell or solid organ transplantation. Ocular involvement is a rare finding in PTLD. OBSERVATION: We report the case of a 38-year-old man who presented with unilateral retinal infiltrates as first manifestation of PTLD relapse. Diagnosis relied on the presence of EBV DNA in anterior chamber fluids and vitrectomy that showed the presence of a B cell clone. Systemic relapse of PTLD was detected 12 weeks after retinal findings. Treatment of ocular disease included systemic injections of rituximab and intravitreal injections of methotrexate, halting the extension of retinal infiltrates. CONCLUSION: Ocular involvement in PTLD is rare and needs to be acknowledged because it can precede a systemic relapse of the hematological condition. Elsevier 2021-08-02 /pmc/articles/PMC8361285/ /pubmed/34409196 http://dx.doi.org/10.1016/j.ajoc.2021.101186 Text en © 2021 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Adam, Mainguy Elise, Philippakis Sutra Del Galy, Aurélien Dinu, Stanescu-Segall Ramin, Tadayoni Bahram, Bodaghi Sophie, Bonnin Sara, Touhami Epstein-Barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement |
title | Epstein-Barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement |
title_full | Epstein-Barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement |
title_fullStr | Epstein-Barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement |
title_full_unstemmed | Epstein-Barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement |
title_short | Epstein-Barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement |
title_sort | epstein-barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361285/ https://www.ncbi.nlm.nih.gov/pubmed/34409196 http://dx.doi.org/10.1016/j.ajoc.2021.101186 |
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