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Optical coherence tomography angiography vessel density parameters in primary open-angle glaucoma
BACKGROUND: Many studies suggest the existence of an alteration of the retinal hemoperfusion in primary open-angle glaucoma. The OCT-A is a novel technique that allows to provide information on retinal microcirculation in a non-invasive way, thus it represents a possible imaging target for the early...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361292/ https://www.ncbi.nlm.nih.gov/pubmed/34408871 http://dx.doi.org/10.1016/j.amsu.2021.102671 |
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author | Khayrallah, Oumayma Mahjoub, Ahmed Ben abdesslam, Nadia Mahjoub, Anis Ghorbel, Mohamed Mahjoub, Hechmi Knani, Leila Krifa, Fathi |
author_facet | Khayrallah, Oumayma Mahjoub, Ahmed Ben abdesslam, Nadia Mahjoub, Anis Ghorbel, Mohamed Mahjoub, Hechmi Knani, Leila Krifa, Fathi |
author_sort | Khayrallah, Oumayma |
collection | PubMed |
description | BACKGROUND: Many studies suggest the existence of an alteration of the retinal hemoperfusion in primary open-angle glaucoma. The OCT-A is a novel technique that allows to provide information on retinal microcirculation in a non-invasive way, thus it represents a possible imaging target for the early diagnosis and follow-up of glaucoma. The aim of our work is to evaluate the contribution of vascular parameters provided by OCT-A and their diagnostic abilities in the different stages of primary open-angle glaucoma. METHOD: This is a prospective cross-sectional study involving 200 eyes of control subjects and 250 eyes of glaucomatous subjects divided into early glaucoma, moderate glaucoma and advanced glaucoma subgroups. They were assessed for MD, LV by visual field, RNFL and GCC thickness by SS-OCT papillary and macular vascular densities by SS-OCT A. RESULTS: OCT-A vessel densities determined in the optic nerve head, in the peripapillary and in the macular regions were significantly lower in glaucomatous eyes. Among the vascular parameters studied the whole image vascular density showed the best diagnostic ability in the discrimination between glaucomatous eyes and healthy eyes with an AUC of 0.949. Nevertheless, the diagnostic ability of vascular parameters remains lower than of the structural parameters RNFL (AUC: 0.981). A significant correlation was found between structural, functional and vascular parameters with r < 0.05. The quadratic non-linear model defines better the relationship between structural, vascular and functional damage in glaucoma. CONCLUSION: The OCT-A plays an important role in the early diagnosis and follow-up of PAOG. It also contributes to the understanding of some aspects of the vascular role in glaucoma. |
format | Online Article Text |
id | pubmed-8361292 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-83612922021-08-17 Optical coherence tomography angiography vessel density parameters in primary open-angle glaucoma Khayrallah, Oumayma Mahjoub, Ahmed Ben abdesslam, Nadia Mahjoub, Anis Ghorbel, Mohamed Mahjoub, Hechmi Knani, Leila Krifa, Fathi Ann Med Surg (Lond) Cross-sectional Study BACKGROUND: Many studies suggest the existence of an alteration of the retinal hemoperfusion in primary open-angle glaucoma. The OCT-A is a novel technique that allows to provide information on retinal microcirculation in a non-invasive way, thus it represents a possible imaging target for the early diagnosis and follow-up of glaucoma. The aim of our work is to evaluate the contribution of vascular parameters provided by OCT-A and their diagnostic abilities in the different stages of primary open-angle glaucoma. METHOD: This is a prospective cross-sectional study involving 200 eyes of control subjects and 250 eyes of glaucomatous subjects divided into early glaucoma, moderate glaucoma and advanced glaucoma subgroups. They were assessed for MD, LV by visual field, RNFL and GCC thickness by SS-OCT papillary and macular vascular densities by SS-OCT A. RESULTS: OCT-A vessel densities determined in the optic nerve head, in the peripapillary and in the macular regions were significantly lower in glaucomatous eyes. Among the vascular parameters studied the whole image vascular density showed the best diagnostic ability in the discrimination between glaucomatous eyes and healthy eyes with an AUC of 0.949. Nevertheless, the diagnostic ability of vascular parameters remains lower than of the structural parameters RNFL (AUC: 0.981). A significant correlation was found between structural, functional and vascular parameters with r < 0.05. The quadratic non-linear model defines better the relationship between structural, vascular and functional damage in glaucoma. CONCLUSION: The OCT-A plays an important role in the early diagnosis and follow-up of PAOG. It also contributes to the understanding of some aspects of the vascular role in glaucoma. Elsevier 2021-08-09 /pmc/articles/PMC8361292/ /pubmed/34408871 http://dx.doi.org/10.1016/j.amsu.2021.102671 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Cross-sectional Study Khayrallah, Oumayma Mahjoub, Ahmed Ben abdesslam, Nadia Mahjoub, Anis Ghorbel, Mohamed Mahjoub, Hechmi Knani, Leila Krifa, Fathi Optical coherence tomography angiography vessel density parameters in primary open-angle glaucoma |
title | Optical coherence tomography angiography vessel density parameters in primary open-angle glaucoma |
title_full | Optical coherence tomography angiography vessel density parameters in primary open-angle glaucoma |
title_fullStr | Optical coherence tomography angiography vessel density parameters in primary open-angle glaucoma |
title_full_unstemmed | Optical coherence tomography angiography vessel density parameters in primary open-angle glaucoma |
title_short | Optical coherence tomography angiography vessel density parameters in primary open-angle glaucoma |
title_sort | optical coherence tomography angiography vessel density parameters in primary open-angle glaucoma |
topic | Cross-sectional Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361292/ https://www.ncbi.nlm.nih.gov/pubmed/34408871 http://dx.doi.org/10.1016/j.amsu.2021.102671 |
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