The ubiquitous mitochondrial protein unfoldase CLPX regulates erythroid heme synthesis by control of iron utilization and heme synthesis enzyme activation and turnover

Heme plays a critical role in catalyzing life-essential redox reactions in all cells, and its synthesis must be tightly balanced with cellular requirements. Heme synthesis in eukaryotes is tightly regulated by the mitochondrial AAA+ unfoldase CLPX (caseinolytic mitochondrial matrix peptidase chapero...

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Detalles Bibliográficos
Autores principales: Rondelli, Catherine M., Perfetto, Mark, Danoff, Aidan, Bergonia, Hector, Gillis, Samantha, O'Neill, Leah, Jackson, Laurie, Nicolas, Gael, Puy, Herve, West, Richard, Phillips, John D., Yien, Yvette Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Accelerated Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361296/
https://www.ncbi.nlm.nih.gov/pubmed/34280433
http://dx.doi.org/10.1016/j.jbc.2021.100972

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