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Amygdala substructure volumes in Major Depressive Disorder

The role of the amygdala in the experience of emotional states and stress is well established. Connections from the amygdala to the hypothalamus activate the hypothalamic–pituitaryadrenal (HPA) axis and the cortisol response. Previous studies have failed to find consistent whole amygdala volume chan...

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Autores principales: Roddy, Darren, Kelly, John R., Farrell, Chloë, Doolin, Kelly, Roman, Elena, Nasa, Anurag, Frodl, Thomas, Harkin, Andrew, O'Mara, Shane, O'Hanlon, Erik, O'Keane, Veronica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361319/
https://www.ncbi.nlm.nih.gov/pubmed/34384996
http://dx.doi.org/10.1016/j.nicl.2021.102781
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author Roddy, Darren
Kelly, John R.
Farrell, Chloë
Doolin, Kelly
Roman, Elena
Nasa, Anurag
Frodl, Thomas
Harkin, Andrew
O'Mara, Shane
O'Hanlon, Erik
O'Keane, Veronica
author_facet Roddy, Darren
Kelly, John R.
Farrell, Chloë
Doolin, Kelly
Roman, Elena
Nasa, Anurag
Frodl, Thomas
Harkin, Andrew
O'Mara, Shane
O'Hanlon, Erik
O'Keane, Veronica
author_sort Roddy, Darren
collection PubMed
description The role of the amygdala in the experience of emotional states and stress is well established. Connections from the amygdala to the hypothalamus activate the hypothalamic–pituitaryadrenal (HPA) axis and the cortisol response. Previous studies have failed to find consistent whole amygdala volume changes in Major Depressive Disorder (MDD), but differences may exist at the smaller substructural level of the amygdala nuclei. High-resolution T1 and T2-weighted-fluid-attenuated inversion recovery MRIs were compared between 80 patients with MDD and 83 healthy controls (HC) using the automated amygdala substructure module in FreeSurfer 6.0. Volumetric assessments were performed for individual nuclei and three anatomico-functional composite groups of nuclei. Salivary cortisol awakening response (CAR), as a measure of HPA responsivity, was measured in a subset of patients. The right medial nucleus volume was larger in MDD compared to HC (p = 0.002). Increased right-left volume ratios were found in MDD for the whole amygdala (p = 0.004), the laterobasal composite (p = 0.009) and in the central (p = 0.003) and medial (p = 0.014) nuclei. The CAR was not significantly different between MDD and HC. Within the MDD group the left corticoamygdaloid transition area was inversely correlated with the CAR, as measured by area under the curve (AUCg) (p ≤ 0.0001). In conclusion, our study found larger right medial nuclei volumes in MDD compared to HC and relatively increased right compared to left whole and substructure volume ratios in MDD. The results suggest that amygdala substructure volumes may be involved in the pathophysiology of state depression.
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spelling pubmed-83613192021-08-17 Amygdala substructure volumes in Major Depressive Disorder Roddy, Darren Kelly, John R. Farrell, Chloë Doolin, Kelly Roman, Elena Nasa, Anurag Frodl, Thomas Harkin, Andrew O'Mara, Shane O'Hanlon, Erik O'Keane, Veronica Neuroimage Clin Regular Article The role of the amygdala in the experience of emotional states and stress is well established. Connections from the amygdala to the hypothalamus activate the hypothalamic–pituitaryadrenal (HPA) axis and the cortisol response. Previous studies have failed to find consistent whole amygdala volume changes in Major Depressive Disorder (MDD), but differences may exist at the smaller substructural level of the amygdala nuclei. High-resolution T1 and T2-weighted-fluid-attenuated inversion recovery MRIs were compared between 80 patients with MDD and 83 healthy controls (HC) using the automated amygdala substructure module in FreeSurfer 6.0. Volumetric assessments were performed for individual nuclei and three anatomico-functional composite groups of nuclei. Salivary cortisol awakening response (CAR), as a measure of HPA responsivity, was measured in a subset of patients. The right medial nucleus volume was larger in MDD compared to HC (p = 0.002). Increased right-left volume ratios were found in MDD for the whole amygdala (p = 0.004), the laterobasal composite (p = 0.009) and in the central (p = 0.003) and medial (p = 0.014) nuclei. The CAR was not significantly different between MDD and HC. Within the MDD group the left corticoamygdaloid transition area was inversely correlated with the CAR, as measured by area under the curve (AUCg) (p ≤ 0.0001). In conclusion, our study found larger right medial nuclei volumes in MDD compared to HC and relatively increased right compared to left whole and substructure volume ratios in MDD. The results suggest that amygdala substructure volumes may be involved in the pathophysiology of state depression. Elsevier 2021-08-08 /pmc/articles/PMC8361319/ /pubmed/34384996 http://dx.doi.org/10.1016/j.nicl.2021.102781 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Regular Article
Roddy, Darren
Kelly, John R.
Farrell, Chloë
Doolin, Kelly
Roman, Elena
Nasa, Anurag
Frodl, Thomas
Harkin, Andrew
O'Mara, Shane
O'Hanlon, Erik
O'Keane, Veronica
Amygdala substructure volumes in Major Depressive Disorder
title Amygdala substructure volumes in Major Depressive Disorder
title_full Amygdala substructure volumes in Major Depressive Disorder
title_fullStr Amygdala substructure volumes in Major Depressive Disorder
title_full_unstemmed Amygdala substructure volumes in Major Depressive Disorder
title_short Amygdala substructure volumes in Major Depressive Disorder
title_sort amygdala substructure volumes in major depressive disorder
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361319/
https://www.ncbi.nlm.nih.gov/pubmed/34384996
http://dx.doi.org/10.1016/j.nicl.2021.102781
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