TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain

RNA binding proteins have been shown to play a key role in the pathogenesis of amyotrophic lateral sclerosis (ALS). Mutations in valosin-containing protein (VCP/p97) cause ALS and exhibit the hallmark nuclear-to-cytoplasmic mislocalization of RNA binding proteins (RBPs). However, the mechanism by wh...

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Detalles Bibliográficos
Autores principales: Harley, Jasmine, Hagemann, Cathleen, Serio, Andrea, Patani, Rickie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361416/
https://www.ncbi.nlm.nih.gov/pubmed/34396115
http://dx.doi.org/10.1093/braincomms/fcab166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361416/
https://www.ncbi.nlm.nih.gov/pubmed/34396115
http://dx.doi.org/10.1093/braincomms/fcab166

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