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Advances in the Development of Biomaterials for Endotoxin Adsorption in Sepsis

Sepsis, a life-threatening and intractable disease without any specific treatment, is activated by endotoxin. Some attempts at removing endotoxin to treat sepsis from the blood circulation using different hemoperfusion cartridges have been proposed recently, but they have failed to reduce the mortal...

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Detalles Bibliográficos
Autores principales: Yang, Qinbo, Li, Yupei, Tuohuti, Pazilaiti, Qin, Zheng, Zhang, Zhuyun, Zhao, Weifeng, Su, Baihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361450/
https://www.ncbi.nlm.nih.gov/pubmed/34395405
http://dx.doi.org/10.3389/fbioe.2021.699418
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author Yang, Qinbo
Li, Yupei
Tuohuti, Pazilaiti
Qin, Zheng
Zhang, Zhuyun
Zhao, Weifeng
Su, Baihai
author_facet Yang, Qinbo
Li, Yupei
Tuohuti, Pazilaiti
Qin, Zheng
Zhang, Zhuyun
Zhao, Weifeng
Su, Baihai
author_sort Yang, Qinbo
collection PubMed
description Sepsis, a life-threatening and intractable disease without any specific treatment, is activated by endotoxin. Some attempts at removing endotoxin to treat sepsis from the blood circulation using different hemoperfusion cartridges have been proposed recently, but they have failed to reduce the mortality of severe septic patients. This review summarizes the latest advances in the development of endotoxin adsorbents. In particular, we highlight two critical parameters for endotoxin adsorbents when they are applied in blood purification: the dissociation constant and the maximum adsorption capacity. We also discuss potential challenges and research directions for the future development of endotoxin adsorbents.
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spelling pubmed-83614502021-08-14 Advances in the Development of Biomaterials for Endotoxin Adsorption in Sepsis Yang, Qinbo Li, Yupei Tuohuti, Pazilaiti Qin, Zheng Zhang, Zhuyun Zhao, Weifeng Su, Baihai Front Bioeng Biotechnol Bioengineering and Biotechnology Sepsis, a life-threatening and intractable disease without any specific treatment, is activated by endotoxin. Some attempts at removing endotoxin to treat sepsis from the blood circulation using different hemoperfusion cartridges have been proposed recently, but they have failed to reduce the mortality of severe septic patients. This review summarizes the latest advances in the development of endotoxin adsorbents. In particular, we highlight two critical parameters for endotoxin adsorbents when they are applied in blood purification: the dissociation constant and the maximum adsorption capacity. We also discuss potential challenges and research directions for the future development of endotoxin adsorbents. Frontiers Media S.A. 2021-07-30 /pmc/articles/PMC8361450/ /pubmed/34395405 http://dx.doi.org/10.3389/fbioe.2021.699418 Text en Copyright © 2021 Yang, Li, Tuohuti, Qin, Zhang, Zhao and Su. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Yang, Qinbo
Li, Yupei
Tuohuti, Pazilaiti
Qin, Zheng
Zhang, Zhuyun
Zhao, Weifeng
Su, Baihai
Advances in the Development of Biomaterials for Endotoxin Adsorption in Sepsis
title Advances in the Development of Biomaterials for Endotoxin Adsorption in Sepsis
title_full Advances in the Development of Biomaterials for Endotoxin Adsorption in Sepsis
title_fullStr Advances in the Development of Biomaterials for Endotoxin Adsorption in Sepsis
title_full_unstemmed Advances in the Development of Biomaterials for Endotoxin Adsorption in Sepsis
title_short Advances in the Development of Biomaterials for Endotoxin Adsorption in Sepsis
title_sort advances in the development of biomaterials for endotoxin adsorption in sepsis
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361450/
https://www.ncbi.nlm.nih.gov/pubmed/34395405
http://dx.doi.org/10.3389/fbioe.2021.699418
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