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Impact of antibiotic pretreatment on cultures in children with osteomyelitis and septic arthritis: a retrospective review
BACKGROUND: In the management of pediatric osteomyelitis or septic arthritis, delay in treatment may affect outcome, while receipt of antibiotics prior to culture may affect culture results. We aimed to determine if pathogen identification decreased in cultures that were pretreated with antibiotics....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361620/ https://www.ncbi.nlm.nih.gov/pubmed/34389010 http://dx.doi.org/10.1186/s12887-021-02806-w |
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author | Lansell, Amanda Vasili, Yasasvi Suchdev, Parminder S. Figueroa, Janet Kirpalani, Anjali |
author_facet | Lansell, Amanda Vasili, Yasasvi Suchdev, Parminder S. Figueroa, Janet Kirpalani, Anjali |
author_sort | Lansell, Amanda |
collection | PubMed |
description | BACKGROUND: In the management of pediatric osteomyelitis or septic arthritis, delay in treatment may affect outcome, while receipt of antibiotics prior to culture may affect culture results. We aimed to determine if pathogen identification decreased in cultures that were pretreated with antibiotics. METHODS: We conducted a retrospective cohort study of 584 hospitalized children between 30 days and 18 years of age admitted to two tertiary children’s hospitals. Logistic regression assessed the effect of antibiotic duration on blood, bone, joint aspirate, and “other” culture positivity. RESULTS: Overall, 42% of blood cultures, 70% of bone cultures, 39% of joint cultures, and 70% of “other” cultures were positive. Compared with children who did not receive antibiotics prior to culture, there were no significant differences in odds of a positive culture in children whose cultures were pretreated with antibiotics for any of the culture types [OR (95% CI) 0.90 (0.56–1.44) for blood cultures, 0.77 (0.25–2.34) for bone cultures, 0.71 (0.39–1.28) for joint cultures, 1.18 (0.58–2.41) “for other” cultures; all p > 0.05]. Furthermore, the duration (hours) of antibiotics in the pretreated cultures was also not a significant predictor of culture positivity (OR ranged from 0.99–1.00 for all cultures, p > 0.05). CONCLUSIONS: Culture positivity was not associated with antibiotic pretreatment in any of the samples, even for longer duration of antibiotics prior to culture, though the small sample size of subgroups is an important limitation. In pediatric patients hospitalized with osteomyelitis and/or septic arthritis, early initiation of antibiotics may not affect culture positivity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-021-02806-w. |
format | Online Article Text |
id | pubmed-8361620 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-83616202021-08-16 Impact of antibiotic pretreatment on cultures in children with osteomyelitis and septic arthritis: a retrospective review Lansell, Amanda Vasili, Yasasvi Suchdev, Parminder S. Figueroa, Janet Kirpalani, Anjali BMC Pediatr Research BACKGROUND: In the management of pediatric osteomyelitis or septic arthritis, delay in treatment may affect outcome, while receipt of antibiotics prior to culture may affect culture results. We aimed to determine if pathogen identification decreased in cultures that were pretreated with antibiotics. METHODS: We conducted a retrospective cohort study of 584 hospitalized children between 30 days and 18 years of age admitted to two tertiary children’s hospitals. Logistic regression assessed the effect of antibiotic duration on blood, bone, joint aspirate, and “other” culture positivity. RESULTS: Overall, 42% of blood cultures, 70% of bone cultures, 39% of joint cultures, and 70% of “other” cultures were positive. Compared with children who did not receive antibiotics prior to culture, there were no significant differences in odds of a positive culture in children whose cultures were pretreated with antibiotics for any of the culture types [OR (95% CI) 0.90 (0.56–1.44) for blood cultures, 0.77 (0.25–2.34) for bone cultures, 0.71 (0.39–1.28) for joint cultures, 1.18 (0.58–2.41) “for other” cultures; all p > 0.05]. Furthermore, the duration (hours) of antibiotics in the pretreated cultures was also not a significant predictor of culture positivity (OR ranged from 0.99–1.00 for all cultures, p > 0.05). CONCLUSIONS: Culture positivity was not associated with antibiotic pretreatment in any of the samples, even for longer duration of antibiotics prior to culture, though the small sample size of subgroups is an important limitation. In pediatric patients hospitalized with osteomyelitis and/or septic arthritis, early initiation of antibiotics may not affect culture positivity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-021-02806-w. BioMed Central 2021-08-13 /pmc/articles/PMC8361620/ /pubmed/34389010 http://dx.doi.org/10.1186/s12887-021-02806-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Lansell, Amanda Vasili, Yasasvi Suchdev, Parminder S. Figueroa, Janet Kirpalani, Anjali Impact of antibiotic pretreatment on cultures in children with osteomyelitis and septic arthritis: a retrospective review |
title | Impact of antibiotic pretreatment on cultures in children with osteomyelitis and septic arthritis: a retrospective review |
title_full | Impact of antibiotic pretreatment on cultures in children with osteomyelitis and septic arthritis: a retrospective review |
title_fullStr | Impact of antibiotic pretreatment on cultures in children with osteomyelitis and septic arthritis: a retrospective review |
title_full_unstemmed | Impact of antibiotic pretreatment on cultures in children with osteomyelitis and septic arthritis: a retrospective review |
title_short | Impact of antibiotic pretreatment on cultures in children with osteomyelitis and septic arthritis: a retrospective review |
title_sort | impact of antibiotic pretreatment on cultures in children with osteomyelitis and septic arthritis: a retrospective review |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361620/ https://www.ncbi.nlm.nih.gov/pubmed/34389010 http://dx.doi.org/10.1186/s12887-021-02806-w |
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