Roles of physical exercise in neurodegeneration: reversal of epigenetic clock

The epigenetic clock is defined by the DNA methylation (DNAm) level and has been extensively applied to distinguish biological age from chronological age. Aging-related neurodegeneration is associated with epigenetic alteration, which determines the status of diseases. In recent years, extensive res...

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Autores principales: Xu, Miao, Zhu, JiaYi, Liu, Xian-Dong, Luo, Ming-Ying, Xu, Nan-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361623/
https://www.ncbi.nlm.nih.gov/pubmed/34389067
http://dx.doi.org/10.1186/s40035-021-00254-1
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author Xu, Miao
Zhu, JiaYi
Liu, Xian-Dong
Luo, Ming-Ying
Xu, Nan-Jie
author_facet Xu, Miao
Zhu, JiaYi
Liu, Xian-Dong
Luo, Ming-Ying
Xu, Nan-Jie
author_sort Xu, Miao
collection PubMed
description The epigenetic clock is defined by the DNA methylation (DNAm) level and has been extensively applied to distinguish biological age from chronological age. Aging-related neurodegeneration is associated with epigenetic alteration, which determines the status of diseases. In recent years, extensive research has shown that physical exercise (PE) can affect the DNAm level, implying a reversal of the epigenetic clock in neurodegeneration. PE also regulates brain plasticity, neuroinflammation, and molecular signaling cascades associated with epigenetics. This review summarizes the effects of PE on neurodegenerative diseases via both general and disease-specific DNAm mechanisms, and discusses epigenetic modifications that alleviate the pathological symptoms of these diseases. This may lead to probing of the underpinnings of neurodegenerative disorders and provide valuable therapeutic references for cognitive and motor dysfunction.
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spelling pubmed-83616232021-08-16 Roles of physical exercise in neurodegeneration: reversal of epigenetic clock Xu, Miao Zhu, JiaYi Liu, Xian-Dong Luo, Ming-Ying Xu, Nan-Jie Transl Neurodegener Review The epigenetic clock is defined by the DNA methylation (DNAm) level and has been extensively applied to distinguish biological age from chronological age. Aging-related neurodegeneration is associated with epigenetic alteration, which determines the status of diseases. In recent years, extensive research has shown that physical exercise (PE) can affect the DNAm level, implying a reversal of the epigenetic clock in neurodegeneration. PE also regulates brain plasticity, neuroinflammation, and molecular signaling cascades associated with epigenetics. This review summarizes the effects of PE on neurodegenerative diseases via both general and disease-specific DNAm mechanisms, and discusses epigenetic modifications that alleviate the pathological symptoms of these diseases. This may lead to probing of the underpinnings of neurodegenerative disorders and provide valuable therapeutic references for cognitive and motor dysfunction. BioMed Central 2021-08-13 /pmc/articles/PMC8361623/ /pubmed/34389067 http://dx.doi.org/10.1186/s40035-021-00254-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Xu, Miao
Zhu, JiaYi
Liu, Xian-Dong
Luo, Ming-Ying
Xu, Nan-Jie
Roles of physical exercise in neurodegeneration: reversal of epigenetic clock
title Roles of physical exercise in neurodegeneration: reversal of epigenetic clock
title_full Roles of physical exercise in neurodegeneration: reversal of epigenetic clock
title_fullStr Roles of physical exercise in neurodegeneration: reversal of epigenetic clock
title_full_unstemmed Roles of physical exercise in neurodegeneration: reversal of epigenetic clock
title_short Roles of physical exercise in neurodegeneration: reversal of epigenetic clock
title_sort roles of physical exercise in neurodegeneration: reversal of epigenetic clock
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361623/
https://www.ncbi.nlm.nih.gov/pubmed/34389067
http://dx.doi.org/10.1186/s40035-021-00254-1
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