Cargando…

The early evolutionary landscape of osteosarcoma provides clues for targeted treatment strategies

Osteosarcomas are aggressive primary tumors of bone that are typically detected in locally advanced stages; however, which genetic mutations drive the cancer before its clinical detection remain unknown. To identify these events, we performed longitudinal genome‐sequencing analysis of 12 patients wi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kovac, Michal, Ameline, Baptiste, Ribi, Sebastian, Kovacova, Monika, Cross, William, Barenboim, Maxim, Witt, Olaf, Bielack, Stefan, Krieg, Andreas, Hartmann, Wolfgang, Nathrath, Michaela, Baumhoer, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2021
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361660/ https://www.ncbi.nlm.nih.gov/pubmed/33963544 http://dx.doi.org/10.1002/path.5699

Ejemplares similares

Overactivation of the IGF signalling pathway in osteosarcoma: a potential therapeutic target?
por: Ameline, Baptiste, et al.
Publicado: (2020)

DNA methylation-based classifier and gene expression signatures detect BRCAness in osteosarcoma
por: Barenboim, Maxim, et al.
Publicado: (2021)

NTRK fusions in osteosarcoma are rare and non‐functional events
por: Ameline, Baptiste, et al.
Publicado: (2020)

Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency
por: Kovac, Michal, et al.
Publicado: (2015)

Osteosarcoma cells with genetic signatures of BRCAness are susceptible to the PARP inhibitor talazoparib alone or in combination with chemotherapeutics
por: Engert, Florian, et al.
Publicado: (2016)

CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patients
por: Baumhoer, Daniel, et al.
Publicado: (2011)

Solitary pulmonary metastases at first recurrence of osteosarcoma: Presentation, treatment, and survival of 219 patients of the Cooperative Osteosarcoma Study Group
por: Mettmann, Vanessa L., et al.
Publicado: (2023)

Structuring osteosarcoma knowledge: an osteosarcoma-gene association database based on literature mining and manual annotation
por: Poos, Kathrin, et al.
Publicado: (2014)

Methylation and copy number profiling: emerging tools to differentiate osteoblastoma from malignant mimics?
por: Ameline, Baptiste, et al.
Publicado: (2022)

How MicroRNA and Transcription Factor Co-regulatory Networks Affect Osteosarcoma Cell Proliferation
por: Poos, Kathrin, et al.
Publicado: (2013)

Genomic Heterogeneity of Osteosarcoma - Shift from Single Candidates to Functional Modules
por: Poos, Kathrin, et al.
Publicado: (2015)

Convergent Evolution of Copy Number Alterations in Multi-Centric Hepatocellular Carcinoma
por: Lackner, Carolin, et al.
Publicado: (2019)

New Small Molecules Targeting Apoptosis and Cell Viability in Osteosarcoma
por: Maugg, Doris, et al.
Publicado: (2015)

Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma – reasons and consequences
por: Arabi, Leila, et al.
Publicado: (2014)

The long non-coding RNA PARTICLE is associated with WWOX and the absence of FRA16D breakage in osteosarcoma patients
por: O'Leary, Valerie Bríd, et al.
Publicado: (2017)

The evolutionary landscape of colorectal tumorigenesis
por: Cross, William, et al.
Publicado: (2018)

Report from the 4th European Bone Sarcoma Networking meeting: focus on osteosarcoma
por: Strauss, Sandra J., et al.
Publicado: (2018)

High-Grade Osteosarcoma of the Foot: Presentation, Treatment, Prognostic Factors, and Outcome of 23 Cooperative Osteosarcoma Study Group COSS Patients
por: Schuster, Anne J., et al.
Publicado: (2018)

TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome
por: Ribi, Sebastian, et al.
Publicado: (2015)

Advances in the management of osteosarcoma
por: Bielack, Stefan S., et al.
Publicado: (2016)

Review of mifamurtide in the treatment of patients with osteosarcoma
por: Kager, Leo, et al.
Publicado: (2010)

Brown Tumors Belong to the Spectrum of KRAS-driven Neoplasms
por: Turek, Daniel, et al.
Publicado: (2022)

A special jubilee: 100 fake osteosarcoma articles
por: Bielack, S.S., et al.
Publicado: (2021)

Osteosarcoma of the Mandible in a Patient with Florid Cemento-Osseous Dysplasia and Li–Fraumeni Syndrome: A Rare Coincidence
por: Haefliger, Simon, et al.
Publicado: (2020)

Ossifying Fibroma of Non-odontogenic Origin: A Fibro-osseous Lesion in the Craniofacial Skeleton to be (Re-)considered
por: Baumhoer, Daniel, et al.
Publicado: (2021)

Metastatic mesenchymal chondrosarcoma showing a sustained response to cabozantinib: A case report
por: Blum, Veronika, et al.
Publicado: (2022)

Genomic Characterization of hox Genes in Senegalese Sole (Solea senegalensis, Kaup 1858): Clues to Evolutionary Path in Pleuronectiformes
por: Mendizábal-Castillero, Marco, et al.
Publicado: (2022)

Beyond germline genetic testing - heterozygous pathogenic variants in PMS2 in two children with Osteosarcoma and Ependymoma
por: Kuhlen, Michaela, et al.
Publicado: (2023)

Recurrent CTNNB1 mutations in craniofacial osteomas
por: Baumhoer, Daniel, et al.
Publicado: (2021)

Immuno-genomic landscape of osteosarcoma
por: Wu, Chia-Chin, et al.
Publicado: (2020)

A complex pattern of chemokine receptor expression is seen in osteosarcoma
por: von Luettichau, Irene, et al.
Publicado: (2008)

Analysis of evolutionary relationships provides new clues to the origins of weedy rice
por: Han, Bing, et al.
Publicado: (2019)

A Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated mice
por: Rosemann, Michael, et al.
Publicado: (2014)

The Landscape of Micro-Inversions Provide Clues for Population Genetic Analysis of Humans
por: Qu, Li, et al.
Publicado: (2020)

Current Insights into the Management of Late Chemotherapy Toxicities in Pediatric Osteosarcoma Patients
por: Hecker-Nolting, Stefanie, et al.
Publicado: (2021)

Metachronous Osteosarcoma, A Differential Diagnosis to be Considered in Children With Osteosarcoma: A Review of Literature and a Case From Our Center
por: Gotta, Jennifer, et al.
Publicado: (2023)

Evolutionary conservation of the eumetazoan gene regulatory landscape
por: Schwaiger, Michaela, et al.
Publicado: (2014)

Osteosarcoma Multi-Omics Landscape and Subtypes
por: Tang, Shan, et al.
Publicado: (2023)

Mapping the Single-cell Differentiation Landscape of Osteosarcoma
por: Truong, Danh D., et al.
Publicado: (2023)

Clinical Landscape of PARP Inhibitors in Ovarian Cancer: Molecular Mechanisms and Clues to Overcome Resistance
por: Kyo, Satoru, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_svhng64plv0v8b0chi0drq5iec