Cargando…

New Insight Into the Cardioprotective Effects of Allium ursinum L. Extract Against Myocardial Ischemia-Reperfusion Injury

This study aimed to estimate the effects of increasing doses of Allium ursinum methanol extract on cardiac ischemia/reperfusion injury (I/R) with a special emphasis on the role of oxidative stress. Fifty rats were randomly divided into five groups (10 animals per group) depending on the applied trea...

Descripción completa

Detalles Bibliográficos
Autores principales: Rankovic, Marina, Krivokapic, Milos, Bradic, Jovana, Petkovic, Anica, Zivkovic, Vladimir, Sretenovic, Jasmina, Jeremic, Nevena, Bolevich, Sergey, Kartashova, Maria, Jeremic, Jovana, Bolevich, Stefani, Jakovljevic, Vladimir, Tomovic, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361798/
https://www.ncbi.nlm.nih.gov/pubmed/34393815
http://dx.doi.org/10.3389/fphys.2021.690696
_version_ 1783738021666881536
author Rankovic, Marina
Krivokapic, Milos
Bradic, Jovana
Petkovic, Anica
Zivkovic, Vladimir
Sretenovic, Jasmina
Jeremic, Nevena
Bolevich, Sergey
Kartashova, Maria
Jeremic, Jovana
Bolevich, Stefani
Jakovljevic, Vladimir
Tomovic, Marina
author_facet Rankovic, Marina
Krivokapic, Milos
Bradic, Jovana
Petkovic, Anica
Zivkovic, Vladimir
Sretenovic, Jasmina
Jeremic, Nevena
Bolevich, Sergey
Kartashova, Maria
Jeremic, Jovana
Bolevich, Stefani
Jakovljevic, Vladimir
Tomovic, Marina
author_sort Rankovic, Marina
collection PubMed
description This study aimed to estimate the effects of increasing doses of Allium ursinum methanol extract on cardiac ischemia/reperfusion injury (I/R) with a special emphasis on the role of oxidative stress. Fifty rats were randomly divided into five groups (10 animals per group) depending on the applied treatment as follows: sham, rats who drank only tap water for 28 days and hearts were retrogradely perfused for 80 min without I/R injury, I/R, rats who drank only tap water for 28 days and hearts were exposed to ex vivo I/R injury and rats who consumed increasing doses of A. ursinum 125, 250, and 500 mg/kg for 28 days before I/R injury. Hearts from all rats were isolated and retrogradely perfused according to the Langendorff technique. Parameters of oxidative stress were spectrophotometrically measured in blood, coronary venous effluent, and heart tissue samples. Intake of wild garlic extract for 28 days significantly contributed to the recovery of cardiac function, which was reflected through preserved cardiac contractility, systolic function, and coronary vasodilatory response after ischemia. Also, wild garlic extract showed the potential to modulate the systemic redox balance and stood out as a powerful antioxidant. The highest dose led to the most efficient decrease in cardiac oxidative stress and improve recovery of myocardial function after I/R injury. We might conclude that wild garlic possesses a significant role in cardioprotection and strong antioxidant activity, which implicates the possibility of its use alone in the prevention or as adjuvant antioxidant therapy in cardiovascular diseases (CVD).
format Online
Article
Text
id pubmed-8361798
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-83617982021-08-14 New Insight Into the Cardioprotective Effects of Allium ursinum L. Extract Against Myocardial Ischemia-Reperfusion Injury Rankovic, Marina Krivokapic, Milos Bradic, Jovana Petkovic, Anica Zivkovic, Vladimir Sretenovic, Jasmina Jeremic, Nevena Bolevich, Sergey Kartashova, Maria Jeremic, Jovana Bolevich, Stefani Jakovljevic, Vladimir Tomovic, Marina Front Physiol Physiology This study aimed to estimate the effects of increasing doses of Allium ursinum methanol extract on cardiac ischemia/reperfusion injury (I/R) with a special emphasis on the role of oxidative stress. Fifty rats were randomly divided into five groups (10 animals per group) depending on the applied treatment as follows: sham, rats who drank only tap water for 28 days and hearts were retrogradely perfused for 80 min without I/R injury, I/R, rats who drank only tap water for 28 days and hearts were exposed to ex vivo I/R injury and rats who consumed increasing doses of A. ursinum 125, 250, and 500 mg/kg for 28 days before I/R injury. Hearts from all rats were isolated and retrogradely perfused according to the Langendorff technique. Parameters of oxidative stress were spectrophotometrically measured in blood, coronary venous effluent, and heart tissue samples. Intake of wild garlic extract for 28 days significantly contributed to the recovery of cardiac function, which was reflected through preserved cardiac contractility, systolic function, and coronary vasodilatory response after ischemia. Also, wild garlic extract showed the potential to modulate the systemic redox balance and stood out as a powerful antioxidant. The highest dose led to the most efficient decrease in cardiac oxidative stress and improve recovery of myocardial function after I/R injury. We might conclude that wild garlic possesses a significant role in cardioprotection and strong antioxidant activity, which implicates the possibility of its use alone in the prevention or as adjuvant antioxidant therapy in cardiovascular diseases (CVD). Frontiers Media S.A. 2021-07-30 /pmc/articles/PMC8361798/ /pubmed/34393815 http://dx.doi.org/10.3389/fphys.2021.690696 Text en Copyright © 2021 Rankovic, Krivokapic, Bradic, Petkovic, Zivkovic, Sretenovic, Jeremic, Bolevich, Kartashova, Jeremic, Bolevich, Jakovljevic and Tomovic. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Rankovic, Marina
Krivokapic, Milos
Bradic, Jovana
Petkovic, Anica
Zivkovic, Vladimir
Sretenovic, Jasmina
Jeremic, Nevena
Bolevich, Sergey
Kartashova, Maria
Jeremic, Jovana
Bolevich, Stefani
Jakovljevic, Vladimir
Tomovic, Marina
New Insight Into the Cardioprotective Effects of Allium ursinum L. Extract Against Myocardial Ischemia-Reperfusion Injury
title New Insight Into the Cardioprotective Effects of Allium ursinum L. Extract Against Myocardial Ischemia-Reperfusion Injury
title_full New Insight Into the Cardioprotective Effects of Allium ursinum L. Extract Against Myocardial Ischemia-Reperfusion Injury
title_fullStr New Insight Into the Cardioprotective Effects of Allium ursinum L. Extract Against Myocardial Ischemia-Reperfusion Injury
title_full_unstemmed New Insight Into the Cardioprotective Effects of Allium ursinum L. Extract Against Myocardial Ischemia-Reperfusion Injury
title_short New Insight Into the Cardioprotective Effects of Allium ursinum L. Extract Against Myocardial Ischemia-Reperfusion Injury
title_sort new insight into the cardioprotective effects of allium ursinum l. extract against myocardial ischemia-reperfusion injury
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361798/
https://www.ncbi.nlm.nih.gov/pubmed/34393815
http://dx.doi.org/10.3389/fphys.2021.690696
work_keys_str_mv AT rankovicmarina newinsightintothecardioprotectiveeffectsofalliumursinumlextractagainstmyocardialischemiareperfusioninjury
AT krivokapicmilos newinsightintothecardioprotectiveeffectsofalliumursinumlextractagainstmyocardialischemiareperfusioninjury
AT bradicjovana newinsightintothecardioprotectiveeffectsofalliumursinumlextractagainstmyocardialischemiareperfusioninjury
AT petkovicanica newinsightintothecardioprotectiveeffectsofalliumursinumlextractagainstmyocardialischemiareperfusioninjury
AT zivkovicvladimir newinsightintothecardioprotectiveeffectsofalliumursinumlextractagainstmyocardialischemiareperfusioninjury
AT sretenovicjasmina newinsightintothecardioprotectiveeffectsofalliumursinumlextractagainstmyocardialischemiareperfusioninjury
AT jeremicnevena newinsightintothecardioprotectiveeffectsofalliumursinumlextractagainstmyocardialischemiareperfusioninjury
AT bolevichsergey newinsightintothecardioprotectiveeffectsofalliumursinumlextractagainstmyocardialischemiareperfusioninjury
AT kartashovamaria newinsightintothecardioprotectiveeffectsofalliumursinumlextractagainstmyocardialischemiareperfusioninjury
AT jeremicjovana newinsightintothecardioprotectiveeffectsofalliumursinumlextractagainstmyocardialischemiareperfusioninjury
AT bolevichstefani newinsightintothecardioprotectiveeffectsofalliumursinumlextractagainstmyocardialischemiareperfusioninjury
AT jakovljevicvladimir newinsightintothecardioprotectiveeffectsofalliumursinumlextractagainstmyocardialischemiareperfusioninjury
AT tomovicmarina newinsightintothecardioprotectiveeffectsofalliumursinumlextractagainstmyocardialischemiareperfusioninjury