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Sex differences in dementia and response to a lifestyle intervention: Evidence from Nordic population‐based studies and a prevention trial
INTRODUCTION: Evidence on sex differences in the risk for dementia has been mixed. The goal was to assess sex differences in the development of dementia, and in the effects of a lifestyle intervention. METHODS: Two strategies were adopted, one using combined data from three large Nordic population‐b...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361986/ https://www.ncbi.nlm.nih.gov/pubmed/34255432 http://dx.doi.org/10.1002/alz.12279 |
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author | Sindi, Shireen Kåreholt, Ingemar Ngandu, Tiia Rosenberg, Anna Kulmala, Jenni Johansson, Lena Wetterberg, Hanna Skoog, Johan Sjöberg, Linnea Wang, Hui‐Xin Fratiglioni, Laura Skoog, Ingmar Kivipelto, Miia |
author_facet | Sindi, Shireen Kåreholt, Ingemar Ngandu, Tiia Rosenberg, Anna Kulmala, Jenni Johansson, Lena Wetterberg, Hanna Skoog, Johan Sjöberg, Linnea Wang, Hui‐Xin Fratiglioni, Laura Skoog, Ingmar Kivipelto, Miia |
author_sort | Sindi, Shireen |
collection | PubMed |
description | INTRODUCTION: Evidence on sex differences in the risk for dementia has been mixed. The goal was to assess sex differences in the development of dementia, and in the effects of a lifestyle intervention. METHODS: Two strategies were adopted, one using combined data from three large Nordic population‐based cohort studies (n = 2289), adopting dementia as outcome, and 2‐year multidomain lifestyle intervention (n = 1260), adopting cognitive change as outcome. RESULTS: There was higher risk for dementia after age 80 years in women. The positive effects of the lifestyle intervention on cognition did not significantly differ between men and women. Sex‐specific analyses suggested that different vascular, lifestyle, and psychosocial risk factors are important for women and men in mid‐ and late‐life. CONCLUSION: Women had higher risk for dementia among the oldest individuals. Lifestyle interventions may be effectively implemented among older men and women. |
format | Online Article Text |
id | pubmed-8361986 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83619862021-08-17 Sex differences in dementia and response to a lifestyle intervention: Evidence from Nordic population‐based studies and a prevention trial Sindi, Shireen Kåreholt, Ingemar Ngandu, Tiia Rosenberg, Anna Kulmala, Jenni Johansson, Lena Wetterberg, Hanna Skoog, Johan Sjöberg, Linnea Wang, Hui‐Xin Fratiglioni, Laura Skoog, Ingmar Kivipelto, Miia Alzheimers Dement Featured Articles INTRODUCTION: Evidence on sex differences in the risk for dementia has been mixed. The goal was to assess sex differences in the development of dementia, and in the effects of a lifestyle intervention. METHODS: Two strategies were adopted, one using combined data from three large Nordic population‐based cohort studies (n = 2289), adopting dementia as outcome, and 2‐year multidomain lifestyle intervention (n = 1260), adopting cognitive change as outcome. RESULTS: There was higher risk for dementia after age 80 years in women. The positive effects of the lifestyle intervention on cognition did not significantly differ between men and women. Sex‐specific analyses suggested that different vascular, lifestyle, and psychosocial risk factors are important for women and men in mid‐ and late‐life. CONCLUSION: Women had higher risk for dementia among the oldest individuals. Lifestyle interventions may be effectively implemented among older men and women. John Wiley and Sons Inc. 2021-07-13 2021-07 /pmc/articles/PMC8361986/ /pubmed/34255432 http://dx.doi.org/10.1002/alz.12279 Text en © 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Featured Articles Sindi, Shireen Kåreholt, Ingemar Ngandu, Tiia Rosenberg, Anna Kulmala, Jenni Johansson, Lena Wetterberg, Hanna Skoog, Johan Sjöberg, Linnea Wang, Hui‐Xin Fratiglioni, Laura Skoog, Ingmar Kivipelto, Miia Sex differences in dementia and response to a lifestyle intervention: Evidence from Nordic population‐based studies and a prevention trial |
title | Sex differences in dementia and response to a lifestyle intervention: Evidence from Nordic population‐based studies and a prevention trial |
title_full | Sex differences in dementia and response to a lifestyle intervention: Evidence from Nordic population‐based studies and a prevention trial |
title_fullStr | Sex differences in dementia and response to a lifestyle intervention: Evidence from Nordic population‐based studies and a prevention trial |
title_full_unstemmed | Sex differences in dementia and response to a lifestyle intervention: Evidence from Nordic population‐based studies and a prevention trial |
title_short | Sex differences in dementia and response to a lifestyle intervention: Evidence from Nordic population‐based studies and a prevention trial |
title_sort | sex differences in dementia and response to a lifestyle intervention: evidence from nordic population‐based studies and a prevention trial |
topic | Featured Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361986/ https://www.ncbi.nlm.nih.gov/pubmed/34255432 http://dx.doi.org/10.1002/alz.12279 |
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