Cobaltoceniumselenolate Gold(I) Complexes: Synthesis, Spectroscopic, Structural and Anticancer Properties

Cobaltoceniumselenolate is an unusual, highly air‐sensitive, mesoionic compound containing a very soft anionic selenium donor atom. Here we explore its coordination chemistry with Au(I) metal centers and show that its hetero‐ and homoleptic gold complexes are highly colored, air‐stable compounds, wh...

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Detalles Bibliográficos
Autores principales: Menia, Daniel, Kopacka, Holger, Wurst, Klaus, Müller, Thomas, Lippmann, Petra, Ott, Ingo, Bildstein, Benno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362036/
https://www.ncbi.nlm.nih.gov/pubmed/34413703
http://dx.doi.org/10.1002/ejic.202100379
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author Menia, Daniel
Kopacka, Holger
Wurst, Klaus
Müller, Thomas
Lippmann, Petra
Ott, Ingo
Bildstein, Benno
author_facet Menia, Daniel
Kopacka, Holger
Wurst, Klaus
Müller, Thomas
Lippmann, Petra
Ott, Ingo
Bildstein, Benno
author_sort Menia, Daniel
collection PubMed
description Cobaltoceniumselenolate is an unusual, highly air‐sensitive, mesoionic compound containing a very soft anionic selenium donor atom. Here we explore its coordination chemistry with Au(I) metal centers and show that its hetero‐ and homoleptic gold complexes are highly colored, air‐stable compounds, which were characterized by (1)H/(13)C/(31)P/(77)Se NMR, IR, UV‐Vis, HR‐MS and single crystal XRD. Cytotoxicity of these polar, water‐soluble complexes was studied against various standard cancer cell lines (A549MDA‐MB‐231, HT‐29) revealing good anticancer activity of all three complexes.
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spelling pubmed-83620362021-08-17 Cobaltoceniumselenolate Gold(I) Complexes: Synthesis, Spectroscopic, Structural and Anticancer Properties Menia, Daniel Kopacka, Holger Wurst, Klaus Müller, Thomas Lippmann, Petra Ott, Ingo Bildstein, Benno Eur J Inorg Chem Communications Cobaltoceniumselenolate is an unusual, highly air‐sensitive, mesoionic compound containing a very soft anionic selenium donor atom. Here we explore its coordination chemistry with Au(I) metal centers and show that its hetero‐ and homoleptic gold complexes are highly colored, air‐stable compounds, which were characterized by (1)H/(13)C/(31)P/(77)Se NMR, IR, UV‐Vis, HR‐MS and single crystal XRD. Cytotoxicity of these polar, water‐soluble complexes was studied against various standard cancer cell lines (A549MDA‐MB‐231, HT‐29) revealing good anticancer activity of all three complexes. John Wiley and Sons Inc. 2021-06-15 2021-07-22 /pmc/articles/PMC8362036/ /pubmed/34413703 http://dx.doi.org/10.1002/ejic.202100379 Text en © 2021 The Authors. European Journal of Inorganic Chemistry published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Menia, Daniel
Kopacka, Holger
Wurst, Klaus
Müller, Thomas
Lippmann, Petra
Ott, Ingo
Bildstein, Benno
Cobaltoceniumselenolate Gold(I) Complexes: Synthesis, Spectroscopic, Structural and Anticancer Properties
title Cobaltoceniumselenolate Gold(I) Complexes: Synthesis, Spectroscopic, Structural and Anticancer Properties
title_full Cobaltoceniumselenolate Gold(I) Complexes: Synthesis, Spectroscopic, Structural and Anticancer Properties
title_fullStr Cobaltoceniumselenolate Gold(I) Complexes: Synthesis, Spectroscopic, Structural and Anticancer Properties
title_full_unstemmed Cobaltoceniumselenolate Gold(I) Complexes: Synthesis, Spectroscopic, Structural and Anticancer Properties
title_short Cobaltoceniumselenolate Gold(I) Complexes: Synthesis, Spectroscopic, Structural and Anticancer Properties
title_sort cobaltoceniumselenolate gold(i) complexes: synthesis, spectroscopic, structural and anticancer properties
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362036/
https://www.ncbi.nlm.nih.gov/pubmed/34413703
http://dx.doi.org/10.1002/ejic.202100379
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