A Unified Approach for the Total Synthesis of cyclo‐Archaeol, iso‐Caldarchaeol, Caldarchaeol, and Mycoketide

Ir‐catalyzed asymmetric alkene hydrogenation is presented as the strategy par excellence to prepare saturated isoprenoids and mycoketides. This highly stereoselective synthesis approach is combined with an established (13)C‐NMR method to determine the enantioselectivity of each methyl‐branched stere...

Descripción completa

Detalles Bibliográficos
Autores principales: Andringa, Ruben L. H., de Kok, Niels A. W., Driessen, Arnold J. M., Minnaard, Adriaan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362178/
https://www.ncbi.nlm.nih.gov/pubmed/33929790
http://dx.doi.org/10.1002/anie.202104759
Descripción
Sumario:Ir‐catalyzed asymmetric alkene hydrogenation is presented as the strategy par excellence to prepare saturated isoprenoids and mycoketides. This highly stereoselective synthesis approach is combined with an established (13)C‐NMR method to determine the enantioselectivity of each methyl‐branched stereocenter. It is shown that this analysis is fit for purpose and the combination allows the synthesis of the title compounds with a significant increase in efficiency.

Ejemplares similares