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Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in China

BACKGROUND: Racial variation exists in the incidence of orofacial granulomatosis (OFG). The epidemiology and clinical characteristics of OFG in Asian countries are poorly described. OBJECTIVE: To describe the epidemiologic and clinical features of OFG in China from data collected on chronic odontoge...

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Autores principales: Wei, Minghui, Xie, Cheng, Liu, Yubo, Wang, Yuhong, Wang, Yuanyuan, Wang, Xinwen, Liu, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362245/
https://www.ncbi.nlm.nih.gov/pubmed/34409334
http://dx.doi.org/10.1016/j.jdin.2020.07.003
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author Wei, Minghui
Xie, Cheng
Liu, Yubo
Wang, Yuhong
Wang, Yuanyuan
Wang, Xinwen
Liu, Yuan
author_facet Wei, Minghui
Xie, Cheng
Liu, Yubo
Wang, Yuhong
Wang, Yuanyuan
Wang, Xinwen
Liu, Yuan
author_sort Wei, Minghui
collection PubMed
description BACKGROUND: Racial variation exists in the incidence of orofacial granulomatosis (OFG). The epidemiology and clinical characteristics of OFG in Asian countries are poorly described. OBJECTIVE: To describe the epidemiologic and clinical features of OFG in China from data collected on chronic odontogenic infection and studied in actual practice regarding the long-term outcome of OFG patients receiving different treatments. METHODS: Data on demographics, medical history, chronic odontogenic infection, and the extent of disease were collected, and long-term outcomes after the end of treatments were evaluated. RESULTS: Of the 165 OFG patients, 118 (71.5%; 95% CI 64.6%-78.5%) had a chronic odontogenic infection. There was a variety of difference between OFG with and without chronic odontogenic infection. Approximately 98.3% (95% confidence interval 94.8%-100%) of OFG patients with chronic odontogenic infection who received dental treatment showed a marked response, of whom 31 patients (53.4%; 95% confidence interval 40.2%-66.7%) had complete remission. LIMITATIONS: Endoscopic investigations were not performed for most of the patients, and more detailed data were not collected, which might have demonstrated additional systemic problems. CONCLUSIONS: OFG with chronic odontogenic infection is the major clinical pattern of OFG in China, which may be a subtype of OFG. Dental treatment should necessarily be the preferred first-line therapy for such patients.
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spelling pubmed-83622452021-08-17 Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in China Wei, Minghui Xie, Cheng Liu, Yubo Wang, Yuhong Wang, Yuanyuan Wang, Xinwen Liu, Yuan JAAD Int Original Article BACKGROUND: Racial variation exists in the incidence of orofacial granulomatosis (OFG). The epidemiology and clinical characteristics of OFG in Asian countries are poorly described. OBJECTIVE: To describe the epidemiologic and clinical features of OFG in China from data collected on chronic odontogenic infection and studied in actual practice regarding the long-term outcome of OFG patients receiving different treatments. METHODS: Data on demographics, medical history, chronic odontogenic infection, and the extent of disease were collected, and long-term outcomes after the end of treatments were evaluated. RESULTS: Of the 165 OFG patients, 118 (71.5%; 95% CI 64.6%-78.5%) had a chronic odontogenic infection. There was a variety of difference between OFG with and without chronic odontogenic infection. Approximately 98.3% (95% confidence interval 94.8%-100%) of OFG patients with chronic odontogenic infection who received dental treatment showed a marked response, of whom 31 patients (53.4%; 95% confidence interval 40.2%-66.7%) had complete remission. LIMITATIONS: Endoscopic investigations were not performed for most of the patients, and more detailed data were not collected, which might have demonstrated additional systemic problems. CONCLUSIONS: OFG with chronic odontogenic infection is the major clinical pattern of OFG in China, which may be a subtype of OFG. Dental treatment should necessarily be the preferred first-line therapy for such patients. Elsevier 2020-08-12 /pmc/articles/PMC8362245/ /pubmed/34409334 http://dx.doi.org/10.1016/j.jdin.2020.07.003 Text en © 2020 by the American Academy of Dermatology, Inc. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Wei, Minghui
Xie, Cheng
Liu, Yubo
Wang, Yuhong
Wang, Yuanyuan
Wang, Xinwen
Liu, Yuan
Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in China
title Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in China
title_full Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in China
title_fullStr Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in China
title_full_unstemmed Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in China
title_short Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in China
title_sort characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in china
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362245/
https://www.ncbi.nlm.nih.gov/pubmed/34409334
http://dx.doi.org/10.1016/j.jdin.2020.07.003
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