Cargando…
Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in China
BACKGROUND: Racial variation exists in the incidence of orofacial granulomatosis (OFG). The epidemiology and clinical characteristics of OFG in Asian countries are poorly described. OBJECTIVE: To describe the epidemiologic and clinical features of OFG in China from data collected on chronic odontoge...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362245/ https://www.ncbi.nlm.nih.gov/pubmed/34409334 http://dx.doi.org/10.1016/j.jdin.2020.07.003 |
_version_ | 1783738122805182464 |
---|---|
author | Wei, Minghui Xie, Cheng Liu, Yubo Wang, Yuhong Wang, Yuanyuan Wang, Xinwen Liu, Yuan |
author_facet | Wei, Minghui Xie, Cheng Liu, Yubo Wang, Yuhong Wang, Yuanyuan Wang, Xinwen Liu, Yuan |
author_sort | Wei, Minghui |
collection | PubMed |
description | BACKGROUND: Racial variation exists in the incidence of orofacial granulomatosis (OFG). The epidemiology and clinical characteristics of OFG in Asian countries are poorly described. OBJECTIVE: To describe the epidemiologic and clinical features of OFG in China from data collected on chronic odontogenic infection and studied in actual practice regarding the long-term outcome of OFG patients receiving different treatments. METHODS: Data on demographics, medical history, chronic odontogenic infection, and the extent of disease were collected, and long-term outcomes after the end of treatments were evaluated. RESULTS: Of the 165 OFG patients, 118 (71.5%; 95% CI 64.6%-78.5%) had a chronic odontogenic infection. There was a variety of difference between OFG with and without chronic odontogenic infection. Approximately 98.3% (95% confidence interval 94.8%-100%) of OFG patients with chronic odontogenic infection who received dental treatment showed a marked response, of whom 31 patients (53.4%; 95% confidence interval 40.2%-66.7%) had complete remission. LIMITATIONS: Endoscopic investigations were not performed for most of the patients, and more detailed data were not collected, which might have demonstrated additional systemic problems. CONCLUSIONS: OFG with chronic odontogenic infection is the major clinical pattern of OFG in China, which may be a subtype of OFG. Dental treatment should necessarily be the preferred first-line therapy for such patients. |
format | Online Article Text |
id | pubmed-8362245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-83622452021-08-17 Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in China Wei, Minghui Xie, Cheng Liu, Yubo Wang, Yuhong Wang, Yuanyuan Wang, Xinwen Liu, Yuan JAAD Int Original Article BACKGROUND: Racial variation exists in the incidence of orofacial granulomatosis (OFG). The epidemiology and clinical characteristics of OFG in Asian countries are poorly described. OBJECTIVE: To describe the epidemiologic and clinical features of OFG in China from data collected on chronic odontogenic infection and studied in actual practice regarding the long-term outcome of OFG patients receiving different treatments. METHODS: Data on demographics, medical history, chronic odontogenic infection, and the extent of disease were collected, and long-term outcomes after the end of treatments were evaluated. RESULTS: Of the 165 OFG patients, 118 (71.5%; 95% CI 64.6%-78.5%) had a chronic odontogenic infection. There was a variety of difference between OFG with and without chronic odontogenic infection. Approximately 98.3% (95% confidence interval 94.8%-100%) of OFG patients with chronic odontogenic infection who received dental treatment showed a marked response, of whom 31 patients (53.4%; 95% confidence interval 40.2%-66.7%) had complete remission. LIMITATIONS: Endoscopic investigations were not performed for most of the patients, and more detailed data were not collected, which might have demonstrated additional systemic problems. CONCLUSIONS: OFG with chronic odontogenic infection is the major clinical pattern of OFG in China, which may be a subtype of OFG. Dental treatment should necessarily be the preferred first-line therapy for such patients. Elsevier 2020-08-12 /pmc/articles/PMC8362245/ /pubmed/34409334 http://dx.doi.org/10.1016/j.jdin.2020.07.003 Text en © 2020 by the American Academy of Dermatology, Inc. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Wei, Minghui Xie, Cheng Liu, Yubo Wang, Yuhong Wang, Yuanyuan Wang, Xinwen Liu, Yuan Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in China |
title | Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in China |
title_full | Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in China |
title_fullStr | Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in China |
title_full_unstemmed | Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in China |
title_short | Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in China |
title_sort | characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in china |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362245/ https://www.ncbi.nlm.nih.gov/pubmed/34409334 http://dx.doi.org/10.1016/j.jdin.2020.07.003 |
work_keys_str_mv | AT weiminghui characterizingdiseasemanifestationsandtreatmentoutcomesamongpatientswithorofacialgranulomatosisinchina AT xiecheng characterizingdiseasemanifestationsandtreatmentoutcomesamongpatientswithorofacialgranulomatosisinchina AT liuyubo characterizingdiseasemanifestationsandtreatmentoutcomesamongpatientswithorofacialgranulomatosisinchina AT wangyuhong characterizingdiseasemanifestationsandtreatmentoutcomesamongpatientswithorofacialgranulomatosisinchina AT wangyuanyuan characterizingdiseasemanifestationsandtreatmentoutcomesamongpatientswithorofacialgranulomatosisinchina AT wangxinwen characterizingdiseasemanifestationsandtreatmentoutcomesamongpatientswithorofacialgranulomatosisinchina AT liuyuan characterizingdiseasemanifestationsandtreatmentoutcomesamongpatientswithorofacialgranulomatosisinchina |