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Spinal astrocyte aldehyde dehydrogenase-2 mediates ethanol metabolism and analgesia in mice

BACKGROUND: Little is known about the targets in the CNS that mediate ethanol analgesia. This study explores the role of spinal astrocyte aldehyde dehydrogenase-2 (ALDH2), a key ethanol-metabolising enzyme, in the analgesic effects of ethanol in mice. METHODS: Astrocyte and hepatocyte ALHD2-deficien...

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Detalles Bibliográficos
Autores principales:	Jin, Shiyun, Cinar, Resat, Hu, Xudong, Lin, Yuhong, Luo, Guoxiang, Lovinger, David M., Zhang, Ye, Zhang, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Laboratory Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362281/ https://www.ncbi.nlm.nih.gov/pubmed/33934892 http://dx.doi.org/10.1016/j.bja.2021.02.035

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