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Intestinal microbiota participates in nonalcoholic fatty liver disease progression by affecting intestinal homeostasis

Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease with a pathogenesis that has not been fully elucidated. With the development of the theory of the gut-liver axis and the deepening of related research, the role of the intestinal tract in the pathogenesis of NAFLD has been investiga...

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Autores principales: Zhang, Yang, Li, Jun-Xiang, Zhang, Yan, Wang, Yun-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362529/
https://www.ncbi.nlm.nih.gov/pubmed/34447812
http://dx.doi.org/10.12998/wjcc.v9.i23.6654
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author Zhang, Yang
Li, Jun-Xiang
Zhang, Yan
Wang, Yun-Liang
author_facet Zhang, Yang
Li, Jun-Xiang
Zhang, Yan
Wang, Yun-Liang
author_sort Zhang, Yang
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease with a pathogenesis that has not been fully elucidated. With the development of the theory of the gut-liver axis and the deepening of related research, the role of the intestinal tract in the pathogenesis of NAFLD has been investigated more. Intestinal microbiota, intestinal metabolites, and intestinal epithelial and immune-based barriers constitute the intestinal environment, which uses crosstalk to maintain the homeostasis of the intestinal environment. This paper reviews the progress in the study of intestinal microbiota, intestinal environment, and NAFLD and suggests that repair of intestinal functional balance may be a new idea for early prevention and intervention of NAFLD.
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spelling pubmed-83625292021-08-25 Intestinal microbiota participates in nonalcoholic fatty liver disease progression by affecting intestinal homeostasis Zhang, Yang Li, Jun-Xiang Zhang, Yan Wang, Yun-Liang World J Clin Cases Minireviews Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease with a pathogenesis that has not been fully elucidated. With the development of the theory of the gut-liver axis and the deepening of related research, the role of the intestinal tract in the pathogenesis of NAFLD has been investigated more. Intestinal microbiota, intestinal metabolites, and intestinal epithelial and immune-based barriers constitute the intestinal environment, which uses crosstalk to maintain the homeostasis of the intestinal environment. This paper reviews the progress in the study of intestinal microbiota, intestinal environment, and NAFLD and suggests that repair of intestinal functional balance may be a new idea for early prevention and intervention of NAFLD. Baishideng Publishing Group Inc 2021-08-16 2021-08-16 /pmc/articles/PMC8362529/ /pubmed/34447812 http://dx.doi.org/10.12998/wjcc.v9.i23.6654 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Minireviews
Zhang, Yang
Li, Jun-Xiang
Zhang, Yan
Wang, Yun-Liang
Intestinal microbiota participates in nonalcoholic fatty liver disease progression by affecting intestinal homeostasis
title Intestinal microbiota participates in nonalcoholic fatty liver disease progression by affecting intestinal homeostasis
title_full Intestinal microbiota participates in nonalcoholic fatty liver disease progression by affecting intestinal homeostasis
title_fullStr Intestinal microbiota participates in nonalcoholic fatty liver disease progression by affecting intestinal homeostasis
title_full_unstemmed Intestinal microbiota participates in nonalcoholic fatty liver disease progression by affecting intestinal homeostasis
title_short Intestinal microbiota participates in nonalcoholic fatty liver disease progression by affecting intestinal homeostasis
title_sort intestinal microbiota participates in nonalcoholic fatty liver disease progression by affecting intestinal homeostasis
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362529/
https://www.ncbi.nlm.nih.gov/pubmed/34447812
http://dx.doi.org/10.12998/wjcc.v9.i23.6654
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