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Risk factors for preoperative carcinogenesis of bile duct cysts in adults

BACKGROUND: Bile duct cyst (BDC) is a rare congenital bile duct malformation. The incidence of bile duct malignancy in BDC patients is markedly higher than that in the general population. However, few studies have been conducted on the risk factors for preoperative carcinogenesis in BDC patients. AI...

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Autores principales: Wu, Xin, Li, Bing-Lu, Zheng, Chao-Ji, He, Xiao-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362564/
https://www.ncbi.nlm.nih.gov/pubmed/34434994
http://dx.doi.org/10.12998/wjcc.v9.i22.6278
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author Wu, Xin
Li, Bing-Lu
Zheng, Chao-Ji
He, Xiao-Dong
author_facet Wu, Xin
Li, Bing-Lu
Zheng, Chao-Ji
He, Xiao-Dong
author_sort Wu, Xin
collection PubMed
description BACKGROUND: Bile duct cyst (BDC) is a rare congenital bile duct malformation. The incidence of bile duct malignancy in BDC patients is markedly higher than that in the general population. However, few studies have been conducted on the risk factors for preoperative carcinogenesis in BDC patients. AIM: To analyze the risk factors associated with preoperative carcinogenesis in BDC patients. METHODS: The medical records of BDC patients treated at our hospital between January 2012 and December 2018 were retrospectively reviewed. We constructed a database and compared the characteristics of BDC patients with dysplasia and carcinoma against those with benign cysts. The risk factors for preoperative carcinogenesis were identified using univariate and multivariate analyses. RESULTS: The cohort comprised 109 BDC patients. Ten patients had preoperative dysplasia or adenocarcinoma. Univariate and multivariate analyses showed that gallbladder wall thickness > 0.3 cm [odds ratio (OR), 6.551; 95% confidence interval (CI), 1.351 to 31.763; P = 0.020] and Todani type IV (OR, 7.675; 95%CI, 1.584 to 37.192; P = 0.011) were independent factors associated with preoperative carcinogenesis. CONCLUSION: BDC is a premalignant condition. Our findings show that gallbladder wall thickness > 0.3 cm and Todani type IV are independent risk factors for preoperative carcinogenesis of BDC. They are therefore useful for deciding on the appropriate treatment strategy, especially in asymptomatic patients.
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spelling pubmed-83625642021-08-24 Risk factors for preoperative carcinogenesis of bile duct cysts in adults Wu, Xin Li, Bing-Lu Zheng, Chao-Ji He, Xiao-Dong World J Clin Cases Retrospective Study BACKGROUND: Bile duct cyst (BDC) is a rare congenital bile duct malformation. The incidence of bile duct malignancy in BDC patients is markedly higher than that in the general population. However, few studies have been conducted on the risk factors for preoperative carcinogenesis in BDC patients. AIM: To analyze the risk factors associated with preoperative carcinogenesis in BDC patients. METHODS: The medical records of BDC patients treated at our hospital between January 2012 and December 2018 were retrospectively reviewed. We constructed a database and compared the characteristics of BDC patients with dysplasia and carcinoma against those with benign cysts. The risk factors for preoperative carcinogenesis were identified using univariate and multivariate analyses. RESULTS: The cohort comprised 109 BDC patients. Ten patients had preoperative dysplasia or adenocarcinoma. Univariate and multivariate analyses showed that gallbladder wall thickness > 0.3 cm [odds ratio (OR), 6.551; 95% confidence interval (CI), 1.351 to 31.763; P = 0.020] and Todani type IV (OR, 7.675; 95%CI, 1.584 to 37.192; P = 0.011) were independent factors associated with preoperative carcinogenesis. CONCLUSION: BDC is a premalignant condition. Our findings show that gallbladder wall thickness > 0.3 cm and Todani type IV are independent risk factors for preoperative carcinogenesis of BDC. They are therefore useful for deciding on the appropriate treatment strategy, especially in asymptomatic patients. Baishideng Publishing Group Inc 2021-08-06 2021-08-06 /pmc/articles/PMC8362564/ /pubmed/34434994 http://dx.doi.org/10.12998/wjcc.v9.i22.6278 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Retrospective Study
Wu, Xin
Li, Bing-Lu
Zheng, Chao-Ji
He, Xiao-Dong
Risk factors for preoperative carcinogenesis of bile duct cysts in adults
title Risk factors for preoperative carcinogenesis of bile duct cysts in adults
title_full Risk factors for preoperative carcinogenesis of bile duct cysts in adults
title_fullStr Risk factors for preoperative carcinogenesis of bile duct cysts in adults
title_full_unstemmed Risk factors for preoperative carcinogenesis of bile duct cysts in adults
title_short Risk factors for preoperative carcinogenesis of bile duct cysts in adults
title_sort risk factors for preoperative carcinogenesis of bile duct cysts in adults
topic Retrospective Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362564/
https://www.ncbi.nlm.nih.gov/pubmed/34434994
http://dx.doi.org/10.12998/wjcc.v9.i22.6278
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