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IL-10 Deficiency Accelerates Type 1 Diabetes Development via Modulation of Innate and Adaptive Immune Cells and Gut Microbiota in BDC2.5 NOD Mice

Type 1 diabetes is an autoimmune disease caused by T cell-mediated destruction of insulin-producing β cells. BDC2.5 T cells in BDC2.5 CD4(+) T cell receptor transgenic Non-Obese Diabetic (NOD) mice (BDC2.5 (+) NOD mice) can abruptly invade the pancreatic islets resulting in severe insulitis that pro...

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Detalles Bibliográficos
Autores principales:	Huang, Juan, Tan, Qiyuan, Tai, Ningwen, Pearson, James Alexander, Li, Yangyang, Chao, Chen, Zhang, Lucy, Peng, Jian, Xing, Yanpeng, Zhang, Luyao, Hu, Youjia, Zhou, Zhiguang, Wong, F. Susan, Wen, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362616/ https://www.ncbi.nlm.nih.gov/pubmed/34394099 http://dx.doi.org/10.3389/fimmu.2021.702955

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