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Long-Term Safety and Tolerability of BMP7 and HGF Gene Overexpression in Rabbit Cornea

PURPOSE: Tissue-targeted localized BMP7+HGF genes delivered into the stroma via nanoparticle effectively treats corneal fibrosis and rehabilitates transparency in vivo without acute toxicity. This study evaluated the long-term safety and tolerability of BMP7+HGF nanomedicine for the eye in vivo. MET...

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Detalles Bibliográficos
Autores principales:	Gupta, Suneel, Sinha, Nishant R., Martin, Lynn M., Keele, Landon M., Sinha, Prashant R., Rodier, Jason T., Landreneau, James R., Hesemann, Nathan P., Mohan, Rajiv R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2021
Materias:	Special Issue
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362627/ https://www.ncbi.nlm.nih.gov/pubmed/34383876 http://dx.doi.org/10.1167/tvst.10.10.6

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