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The efficacy of antimalarial drugs in the therapy of selected forms of cicatricial alopecia
INTRODUCTION: Frontal fibrosing alopecia (FFA) is primary lymphocytic cicatricial alopecia with a clinically characteristic progressive recession of the frontotemporal hairline, perifollicular erythema, as well as symptoms of itching and burning. It occurs mainly in postmenopausal women. FFA is cons...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362748/ https://www.ncbi.nlm.nih.gov/pubmed/34408598 http://dx.doi.org/10.5114/ada.2021.106208 |
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author | Zbiciak-Nylec, Martyna A. Brzezińska-Wcisło, Ligia Salwowska, Natalia |
author_facet | Zbiciak-Nylec, Martyna A. Brzezińska-Wcisło, Ligia Salwowska, Natalia |
author_sort | Zbiciak-Nylec, Martyna A. |
collection | PubMed |
description | INTRODUCTION: Frontal fibrosing alopecia (FFA) is primary lymphocytic cicatricial alopecia with a clinically characteristic progressive recession of the frontotemporal hairline, perifollicular erythema, as well as symptoms of itching and burning. It occurs mainly in postmenopausal women. FFA is considered as a subtype of lichen planopilaris (LPP). The treatment of those diseases is presently empirical. AIM: To define the efficacy of treating FFA and LPP with hydroxychloroquine. MATERIAL AND METHODS: We performed a retrospective analysis of 95 women, including 35 with FFA and 60 with LPP. We collected the relevant demographic and clinical data. The response to treatment with hydroxychloroquine was assessed using LPPAI. Also, adverse events were monitored. RESULTS: Treatment with hydroxychloroquine has a statistically significant effect on decreasing the disease activity after 6 and 12 months of therapy. The results of statistical tests do not confirm the existence of a relationship between age range and treatment efficacy. However, there is a correlation between the duration and efficacy of treatment (p < 0.05). CONCLUSIONS: Administration of hydroxychloroquine can be considered as one of the treatment methods for FFA and LPP in everyday clinical practice. The presented study is the first attempt at using hydroxychloroquine to treat such large patient groups for FFA and LPP. Hydroxychloroquine efficaciously alleviates the symptoms in LPP patients and gives maximum benefits in long-term therapy (12 months). The preliminary results obtained in the presented retrospective analysis should be confirmed in a randomized prospective clinical trial, which remains a future challenge for researchers. |
format | Online Article Text |
id | pubmed-8362748 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-83627482021-08-17 The efficacy of antimalarial drugs in the therapy of selected forms of cicatricial alopecia Zbiciak-Nylec, Martyna A. Brzezińska-Wcisło, Ligia Salwowska, Natalia Postepy Dermatol Alergol Original Paper INTRODUCTION: Frontal fibrosing alopecia (FFA) is primary lymphocytic cicatricial alopecia with a clinically characteristic progressive recession of the frontotemporal hairline, perifollicular erythema, as well as symptoms of itching and burning. It occurs mainly in postmenopausal women. FFA is considered as a subtype of lichen planopilaris (LPP). The treatment of those diseases is presently empirical. AIM: To define the efficacy of treating FFA and LPP with hydroxychloroquine. MATERIAL AND METHODS: We performed a retrospective analysis of 95 women, including 35 with FFA and 60 with LPP. We collected the relevant demographic and clinical data. The response to treatment with hydroxychloroquine was assessed using LPPAI. Also, adverse events were monitored. RESULTS: Treatment with hydroxychloroquine has a statistically significant effect on decreasing the disease activity after 6 and 12 months of therapy. The results of statistical tests do not confirm the existence of a relationship between age range and treatment efficacy. However, there is a correlation between the duration and efficacy of treatment (p < 0.05). CONCLUSIONS: Administration of hydroxychloroquine can be considered as one of the treatment methods for FFA and LPP in everyday clinical practice. The presented study is the first attempt at using hydroxychloroquine to treat such large patient groups for FFA and LPP. Hydroxychloroquine efficaciously alleviates the symptoms in LPP patients and gives maximum benefits in long-term therapy (12 months). The preliminary results obtained in the presented retrospective analysis should be confirmed in a randomized prospective clinical trial, which remains a future challenge for researchers. Termedia Publishing House 2021-05-22 2021-04 /pmc/articles/PMC8362748/ /pubmed/34408598 http://dx.doi.org/10.5114/ada.2021.106208 Text en Copyright © 2021 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) ) |
spellingShingle | Original Paper Zbiciak-Nylec, Martyna A. Brzezińska-Wcisło, Ligia Salwowska, Natalia The efficacy of antimalarial drugs in the therapy of selected forms of cicatricial alopecia |
title | The efficacy of antimalarial drugs in the therapy of selected forms of cicatricial alopecia |
title_full | The efficacy of antimalarial drugs in the therapy of selected forms of cicatricial alopecia |
title_fullStr | The efficacy of antimalarial drugs in the therapy of selected forms of cicatricial alopecia |
title_full_unstemmed | The efficacy of antimalarial drugs in the therapy of selected forms of cicatricial alopecia |
title_short | The efficacy of antimalarial drugs in the therapy of selected forms of cicatricial alopecia |
title_sort | efficacy of antimalarial drugs in the therapy of selected forms of cicatricial alopecia |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362748/ https://www.ncbi.nlm.nih.gov/pubmed/34408598 http://dx.doi.org/10.5114/ada.2021.106208 |
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