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Safety of bronchodilator reversibility test in elderly subjects: a prospective study
INTRODUCTION: The reversibility test measures an increase in ventilation parameters after the administration of 400 mg of a short-acting β-agonist (SABA). It is worth noting that a typical dosage, applied as a rescue medicine for bronchospastic dyspnoea, is significantly less, i.e., 100–200 mg. AIM:...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362750/ https://www.ncbi.nlm.nih.gov/pubmed/34408593 http://dx.doi.org/10.5114/ada.2020.92515 |
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author | Dor-Wojnarowska, Anna Parużyńska, Anna Kulczak, Aleksandra Majewska-Pulsakowska, Marta Szymala-Pędzik, Małgorzata Machaj, Zbigniew Sobieszczańska, Małgorzata Poręba, Małgorzata |
author_facet | Dor-Wojnarowska, Anna Parużyńska, Anna Kulczak, Aleksandra Majewska-Pulsakowska, Marta Szymala-Pędzik, Małgorzata Machaj, Zbigniew Sobieszczańska, Małgorzata Poręba, Małgorzata |
author_sort | Dor-Wojnarowska, Anna |
collection | PubMed |
description | INTRODUCTION: The reversibility test measures an increase in ventilation parameters after the administration of 400 mg of a short-acting β-agonist (SABA). It is worth noting that a typical dosage, applied as a rescue medicine for bronchospastic dyspnoea, is significantly less, i.e., 100–200 mg. AIM: To assess the effects of inhaled 400 mg fenoterol (in the bronchodilator reversibility test) on the heart rate and the development of tachyarrhythmias in subjects aged 65 and above. MATERIAL AND METHODS: A total of 53 subjects (45 women) aged 77; 68–82 (median; interquartile range) in stable clinical condition were included in the study. Data including medical history, physical examinations, blood biochemistry, chest X-ray, 12-lead electrocardiogram, 24-hour Holter ECG monitoring, bronchodilator test, and echocardiography were obtained. During the Holter ECG monitoring, the bronchodilator test using 400 mg fenoterol (Berotec pMDI) was performed. RESULTS: A slight but statistically significant (p = 0.02) increase in heart rate from 71 to 75 per min (median) was noted after the administration of fenoterol. No statistically significant differences were found in the number of extrasystolic beats of either supraventricular (p = 0.42) or ventricular origin (p = 0.50). In addition, the subjects did not show any potentially dangerous arrhythmias or significant signs of coronary artery disease. However, there was a significant increase in the number of supraventricular beats in the subjects who were not taking β-blockers. CONCLUSIONS: The use of 400 mg fenoterol in a bronchodilator reversibility test in elderly subjects does not entail any significant cardiovascular risk. |
format | Online Article Text |
id | pubmed-8362750 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-83627502021-08-17 Safety of bronchodilator reversibility test in elderly subjects: a prospective study Dor-Wojnarowska, Anna Parużyńska, Anna Kulczak, Aleksandra Majewska-Pulsakowska, Marta Szymala-Pędzik, Małgorzata Machaj, Zbigniew Sobieszczańska, Małgorzata Poręba, Małgorzata Postepy Dermatol Alergol Original Paper INTRODUCTION: The reversibility test measures an increase in ventilation parameters after the administration of 400 mg of a short-acting β-agonist (SABA). It is worth noting that a typical dosage, applied as a rescue medicine for bronchospastic dyspnoea, is significantly less, i.e., 100–200 mg. AIM: To assess the effects of inhaled 400 mg fenoterol (in the bronchodilator reversibility test) on the heart rate and the development of tachyarrhythmias in subjects aged 65 and above. MATERIAL AND METHODS: A total of 53 subjects (45 women) aged 77; 68–82 (median; interquartile range) in stable clinical condition were included in the study. Data including medical history, physical examinations, blood biochemistry, chest X-ray, 12-lead electrocardiogram, 24-hour Holter ECG monitoring, bronchodilator test, and echocardiography were obtained. During the Holter ECG monitoring, the bronchodilator test using 400 mg fenoterol (Berotec pMDI) was performed. RESULTS: A slight but statistically significant (p = 0.02) increase in heart rate from 71 to 75 per min (median) was noted after the administration of fenoterol. No statistically significant differences were found in the number of extrasystolic beats of either supraventricular (p = 0.42) or ventricular origin (p = 0.50). In addition, the subjects did not show any potentially dangerous arrhythmias or significant signs of coronary artery disease. However, there was a significant increase in the number of supraventricular beats in the subjects who were not taking β-blockers. CONCLUSIONS: The use of 400 mg fenoterol in a bronchodilator reversibility test in elderly subjects does not entail any significant cardiovascular risk. Termedia Publishing House 2020-02-19 2021-04 /pmc/articles/PMC8362750/ /pubmed/34408593 http://dx.doi.org/10.5114/ada.2020.92515 Text en Copyright © 2021 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) ) |
spellingShingle | Original Paper Dor-Wojnarowska, Anna Parużyńska, Anna Kulczak, Aleksandra Majewska-Pulsakowska, Marta Szymala-Pędzik, Małgorzata Machaj, Zbigniew Sobieszczańska, Małgorzata Poręba, Małgorzata Safety of bronchodilator reversibility test in elderly subjects: a prospective study |
title | Safety of bronchodilator reversibility test in elderly subjects: a prospective study |
title_full | Safety of bronchodilator reversibility test in elderly subjects: a prospective study |
title_fullStr | Safety of bronchodilator reversibility test in elderly subjects: a prospective study |
title_full_unstemmed | Safety of bronchodilator reversibility test in elderly subjects: a prospective study |
title_short | Safety of bronchodilator reversibility test in elderly subjects: a prospective study |
title_sort | safety of bronchodilator reversibility test in elderly subjects: a prospective study |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362750/ https://www.ncbi.nlm.nih.gov/pubmed/34408593 http://dx.doi.org/10.5114/ada.2020.92515 |
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