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Affective temperament, depressive symptoms and interleukins in patients with psoriasis

INTRODUCTION: Psoriasis is a chronic inflammatory skin disease, in which psychological factors play an important role. In the studies of common markers of psoriasis and depression, the abnormal function of the stress axis in both diseases is highlighted, whereas interleukin-6 (IL-6) and interleukin-...

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Autores principales: Marek-Józefowicz, Luiza, Jaracz, Marcin, Borkowska, Alina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362774/
https://www.ncbi.nlm.nih.gov/pubmed/34408580
http://dx.doi.org/10.5114/ada.2021.104289
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author Marek-Józefowicz, Luiza
Jaracz, Marcin
Borkowska, Alina
author_facet Marek-Józefowicz, Luiza
Jaracz, Marcin
Borkowska, Alina
author_sort Marek-Józefowicz, Luiza
collection PubMed
description INTRODUCTION: Psoriasis is a chronic inflammatory skin disease, in which psychological factors play an important role. In the studies of common markers of psoriasis and depression, the abnormal function of the stress axis in both diseases is highlighted, whereas interleukin-6 (IL-6) and interleukin-1 are indicated as particularly important. AIM: To evaluate the relationship between the affective temperament traits and the intensity of depressive symptoms in patients with psoriasis in the context of immunoenzymatic markers. MATERIAL AND METHODS: The study included 208 subjects. Severity of psoriasis was assessed by PASI. TEMPS-A was applied for the evaluation of affective temperament and BDI was used for the assessment of the intensity of depressive symptoms. The level of cytokines was determined by means of the immunoenzymatic method. RESULTS: Patients presented a specific profile of affective temperament, with higher scores on depressive, anxious and irritable dimensions. The severity of depressive symptoms correlated positively with the severity of psoriasis. A significant correlation was found between IL-6 and the severity of psoriasis in patients with depressive disorders and psoriasis. No similar correlation was found in patients without depressive disorder. CONCLUSIONS: Results of the present study show common mechanisms for psoriasis and depression. Specific traits of affective temperament may play an important role in the clinical picture of both diseases. Higher levels of IL-6 in patients with psoriasis predispose to more frequent occurrence of depressive disorders and the depressive dimension of affective temperament.
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spelling pubmed-83627742021-08-17 Affective temperament, depressive symptoms and interleukins in patients with psoriasis Marek-Józefowicz, Luiza Jaracz, Marcin Borkowska, Alina Postepy Dermatol Alergol Original Paper INTRODUCTION: Psoriasis is a chronic inflammatory skin disease, in which psychological factors play an important role. In the studies of common markers of psoriasis and depression, the abnormal function of the stress axis in both diseases is highlighted, whereas interleukin-6 (IL-6) and interleukin-1 are indicated as particularly important. AIM: To evaluate the relationship between the affective temperament traits and the intensity of depressive symptoms in patients with psoriasis in the context of immunoenzymatic markers. MATERIAL AND METHODS: The study included 208 subjects. Severity of psoriasis was assessed by PASI. TEMPS-A was applied for the evaluation of affective temperament and BDI was used for the assessment of the intensity of depressive symptoms. The level of cytokines was determined by means of the immunoenzymatic method. RESULTS: Patients presented a specific profile of affective temperament, with higher scores on depressive, anxious and irritable dimensions. The severity of depressive symptoms correlated positively with the severity of psoriasis. A significant correlation was found between IL-6 and the severity of psoriasis in patients with depressive disorders and psoriasis. No similar correlation was found in patients without depressive disorder. CONCLUSIONS: Results of the present study show common mechanisms for psoriasis and depression. Specific traits of affective temperament may play an important role in the clinical picture of both diseases. Higher levels of IL-6 in patients with psoriasis predispose to more frequent occurrence of depressive disorders and the depressive dimension of affective temperament. Termedia Publishing House 2021-03-10 2021-02 /pmc/articles/PMC8362774/ /pubmed/34408580 http://dx.doi.org/10.5114/ada.2021.104289 Text en Copyright © 2021 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) )
spellingShingle Original Paper
Marek-Józefowicz, Luiza
Jaracz, Marcin
Borkowska, Alina
Affective temperament, depressive symptoms and interleukins in patients with psoriasis
title Affective temperament, depressive symptoms and interleukins in patients with psoriasis
title_full Affective temperament, depressive symptoms and interleukins in patients with psoriasis
title_fullStr Affective temperament, depressive symptoms and interleukins in patients with psoriasis
title_full_unstemmed Affective temperament, depressive symptoms and interleukins in patients with psoriasis
title_short Affective temperament, depressive symptoms and interleukins in patients with psoriasis
title_sort affective temperament, depressive symptoms and interleukins in patients with psoriasis
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362774/
https://www.ncbi.nlm.nih.gov/pubmed/34408580
http://dx.doi.org/10.5114/ada.2021.104289
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