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Tumor Growth in the High Frequency Medulloblastoma Mouse Model Ptch1(+/−)/Tis21(KO) Has a Specific Activation Signature of the PI3K/AKT/mTOR Pathway and Is Counteracted by the PI3K Inhibitor MEN1611

We have previously generated a mouse model (Ptch1(+/−)/Tis21(KO)), which displays high frequency spontaneous medulloblastoma, a pediatric tumor of the cerebellum. Early postnatal cerebellar granule cell precursors (GCPs) of this model show, in consequence of the deletion of Tis21, a defect of the Cx...

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Detalles Bibliográficos
Autores principales:	Ceccarelli, Manuela, D’Andrea, Giorgio, Micheli, Laura, Gentile, Giulia, Cavallaro, Sebastiano, Merlino, Giuseppe, Papoff, Giuliana, Tirone, Felice
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362831/ https://www.ncbi.nlm.nih.gov/pubmed/34395258 http://dx.doi.org/10.3389/fonc.2021.692053

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