Mouse papillomavirus type 1 (MmuPV1) DNA is frequently integrated in benign tumors by microhomology-mediated end-joining

MmuPV1 is a useful model for studying papillomavirus-induced tumorigenesis. We used RNA-seq to look for chimeric RNAs that map to both MmuPV1 and host genomes. In tumor tissues, a higher proportion of total viral reads were virus-host chimeric junction reads (CJRs) (1.9‰ - 7‰) than in tumor-free tis...

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Detalles Bibliográficos
Autores principales: Yu, Lulu, Majerciak, Vladimir, Xue, Xiang-Yang, Uberoi, Aayushi, Lobanov, Alexei, Chen, Xiongfong, Cam, Maggie, Hughes, Stephen H., Lambert, Paul F., Zheng, Zhi-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362953/
https://www.ncbi.nlm.nih.gov/pubmed/34343212
http://dx.doi.org/10.1371/journal.ppat.1009812

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