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Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation

In this work two types of biodegradable polysuccinimide-based, electrospun fibrous membranes are presented. One contains disulfide bonds exhibiting a shorter (3 days) in vivo biodegradation time, while the other one has alkyl crosslinks and a longer biodegradation time (more than 7 days). According...

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Autores principales: Molnar, Kristof, Voniatis, Constantinos, Feher, Daniella, Szabo, Gyorgyi, Varga, Rita, Reiniger, Lilla, Juriga, David, Kiss, Zoltan, Krisch, Eniko, Weber, Gyorgy, Ferencz, Andrea, Varga, Gabor, Zrinyi, Miklos, Nagy, Krisztina S., Jedlovszky-Hajdu, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362958/
https://www.ncbi.nlm.nih.gov/pubmed/34388163
http://dx.doi.org/10.1371/journal.pone.0254843
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author Molnar, Kristof
Voniatis, Constantinos
Feher, Daniella
Szabo, Gyorgyi
Varga, Rita
Reiniger, Lilla
Juriga, David
Kiss, Zoltan
Krisch, Eniko
Weber, Gyorgy
Ferencz, Andrea
Varga, Gabor
Zrinyi, Miklos
Nagy, Krisztina S.
Jedlovszky-Hajdu, Angela
author_facet Molnar, Kristof
Voniatis, Constantinos
Feher, Daniella
Szabo, Gyorgyi
Varga, Rita
Reiniger, Lilla
Juriga, David
Kiss, Zoltan
Krisch, Eniko
Weber, Gyorgy
Ferencz, Andrea
Varga, Gabor
Zrinyi, Miklos
Nagy, Krisztina S.
Jedlovszky-Hajdu, Angela
author_sort Molnar, Kristof
collection PubMed
description In this work two types of biodegradable polysuccinimide-based, electrospun fibrous membranes are presented. One contains disulfide bonds exhibiting a shorter (3 days) in vivo biodegradation time, while the other one has alkyl crosslinks and a longer biodegradation time (more than 7 days). According to the mechanical measurements, the tensile strength of the membranes is comparable to those of soft the connective tissues and visceral tissues. Furthermore, the suture retention test suggests, that the membranes would withstand surgical handling and in vivo fixation. The in vivo biocompatibility study demonstrates how membranes undergo in vivo hydrolysis and by the 3(rd) day they become poly(aspartic acid) fibrous membranes, which can be then enzymatically degraded. After one week, the disulfide crosslinked membranes almost completely degrade, while the alkyl-chain crosslinked ones mildly lose their integrity as the surrounding tissue invades them. Histopathology revealed mild acute inflammation, which diminished to a minimal level after seven days.
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spelling pubmed-83629582021-08-14 Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation Molnar, Kristof Voniatis, Constantinos Feher, Daniella Szabo, Gyorgyi Varga, Rita Reiniger, Lilla Juriga, David Kiss, Zoltan Krisch, Eniko Weber, Gyorgy Ferencz, Andrea Varga, Gabor Zrinyi, Miklos Nagy, Krisztina S. Jedlovszky-Hajdu, Angela PLoS One Research Article In this work two types of biodegradable polysuccinimide-based, electrospun fibrous membranes are presented. One contains disulfide bonds exhibiting a shorter (3 days) in vivo biodegradation time, while the other one has alkyl crosslinks and a longer biodegradation time (more than 7 days). According to the mechanical measurements, the tensile strength of the membranes is comparable to those of soft the connective tissues and visceral tissues. Furthermore, the suture retention test suggests, that the membranes would withstand surgical handling and in vivo fixation. The in vivo biocompatibility study demonstrates how membranes undergo in vivo hydrolysis and by the 3(rd) day they become poly(aspartic acid) fibrous membranes, which can be then enzymatically degraded. After one week, the disulfide crosslinked membranes almost completely degrade, while the alkyl-chain crosslinked ones mildly lose their integrity as the surrounding tissue invades them. Histopathology revealed mild acute inflammation, which diminished to a minimal level after seven days. Public Library of Science 2021-08-13 /pmc/articles/PMC8362958/ /pubmed/34388163 http://dx.doi.org/10.1371/journal.pone.0254843 Text en © 2021 Molnar et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Molnar, Kristof
Voniatis, Constantinos
Feher, Daniella
Szabo, Gyorgyi
Varga, Rita
Reiniger, Lilla
Juriga, David
Kiss, Zoltan
Krisch, Eniko
Weber, Gyorgy
Ferencz, Andrea
Varga, Gabor
Zrinyi, Miklos
Nagy, Krisztina S.
Jedlovszky-Hajdu, Angela
Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation
title Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation
title_full Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation
title_fullStr Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation
title_full_unstemmed Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation
title_short Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation
title_sort poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362958/
https://www.ncbi.nlm.nih.gov/pubmed/34388163
http://dx.doi.org/10.1371/journal.pone.0254843
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