Development of mammary cancer in γ-irradiated F(1) hybrids of susceptible Sprague-Dawley and resistant Copenhagen rats, with copy-number losses that pinpoint potential tumor suppressors

Copenhagen rats are highly resistant to mammary carcinogenesis, even after treatment with chemical carcinogens and hormones; most studies indicate that this is a dominant genetic trait. To test whether this trait is also dominant after radiation exposure, we characterized the susceptibility of irrad...

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Detalles Bibliográficos
Autores principales: Nishimura, Mayumi, Daino, Kazuhiro, Fukuda, Maki, Tanaka, Ikuya, Moriyama, Hitomi, Showler, Kaye, Nishimura, Yukiko, Takabatake, Masaru, Kokubo, Toshiaki, Ishikawa, Atsuko, Inoue, Kazumasa, Fukushi, Masahiro, Kakinuma, Shizuko, Imaoka, Tatsuhiko, Shimada, Yoshiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362979/
https://www.ncbi.nlm.nih.gov/pubmed/34388197
http://dx.doi.org/10.1371/journal.pone.0255968

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