The Evolution of Single-Cell Analysis and Utility in Drug Development

This review provides a brief history of the advances of cellular analysis tools focusing on instrumentation, detection probes, and data analysis tools. The interplay of technological advancement and a deeper understanding of cellular biology are emphasized. The relevance of this topic to drug develo...

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Detalles Bibliográficos
Autores principales: Mitra-Kaushik, Shibani, Mehta-Damani, Anita, Stewart, Jennifer J., Green, Cherie, Litwin, Virginia, Gonneau, Christèle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363238/
https://www.ncbi.nlm.nih.gov/pubmed/34389904
http://dx.doi.org/10.1208/s12248-021-00633-6
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author Mitra-Kaushik, Shibani
Mehta-Damani, Anita
Stewart, Jennifer J.
Green, Cherie
Litwin, Virginia
Gonneau, Christèle
author_facet Mitra-Kaushik, Shibani
Mehta-Damani, Anita
Stewart, Jennifer J.
Green, Cherie
Litwin, Virginia
Gonneau, Christèle
author_sort Mitra-Kaushik, Shibani
collection PubMed
description This review provides a brief history of the advances of cellular analysis tools focusing on instrumentation, detection probes, and data analysis tools. The interplay of technological advancement and a deeper understanding of cellular biology are emphasized. The relevance of this topic to drug development is that the evaluation of cellular biomarkers has become a critical component of the development strategy for novel immune therapies, cell therapies, gene therapies, antiviral therapies, and vaccines. Moreover, recent technological advances in single-cell analysis are providing more robust cellular measurements and thus accelerating the advancement of novel therapies. Graphical abstract [Image: see text]
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spelling pubmed-83632382021-08-15 The Evolution of Single-Cell Analysis and Utility in Drug Development Mitra-Kaushik, Shibani Mehta-Damani, Anita Stewart, Jennifer J. Green, Cherie Litwin, Virginia Gonneau, Christèle AAPS J Review Article This review provides a brief history of the advances of cellular analysis tools focusing on instrumentation, detection probes, and data analysis tools. The interplay of technological advancement and a deeper understanding of cellular biology are emphasized. The relevance of this topic to drug development is that the evaluation of cellular biomarkers has become a critical component of the development strategy for novel immune therapies, cell therapies, gene therapies, antiviral therapies, and vaccines. Moreover, recent technological advances in single-cell analysis are providing more robust cellular measurements and thus accelerating the advancement of novel therapies. Graphical abstract [Image: see text] Springer International Publishing 2021-08-13 /pmc/articles/PMC8363238/ /pubmed/34389904 http://dx.doi.org/10.1208/s12248-021-00633-6 Text en © American Association of Pharmaceutical Scientists 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Mitra-Kaushik, Shibani
Mehta-Damani, Anita
Stewart, Jennifer J.
Green, Cherie
Litwin, Virginia
Gonneau, Christèle
The Evolution of Single-Cell Analysis and Utility in Drug Development
title The Evolution of Single-Cell Analysis and Utility in Drug Development
title_full The Evolution of Single-Cell Analysis and Utility in Drug Development
title_fullStr The Evolution of Single-Cell Analysis and Utility in Drug Development
title_full_unstemmed The Evolution of Single-Cell Analysis and Utility in Drug Development
title_short The Evolution of Single-Cell Analysis and Utility in Drug Development
title_sort evolution of single-cell analysis and utility in drug development
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363238/
https://www.ncbi.nlm.nih.gov/pubmed/34389904
http://dx.doi.org/10.1208/s12248-021-00633-6
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