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Prenatal Depression, Breastfeeding, and Infant Gut Microbiota

Depressive symptoms are common during pregnancy and are estimated to affect 7–20% of pregnant women, with higher prevalence found in those with a prior history of depression, in ethnic minorities, and those with increased exposure to stressful life events. Maternal depression often remains undiagnos...

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Autores principales: Rodriguez, Nicole, Tun, Hein M., Field, Catherine J., Mandhane, Piushkumar J., Scott, James A., Kozyrskyj, Anita L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363245/
https://www.ncbi.nlm.nih.gov/pubmed/34394021
http://dx.doi.org/10.3389/fmicb.2021.664257
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author Rodriguez, Nicole
Tun, Hein M.
Field, Catherine J.
Mandhane, Piushkumar J.
Scott, James A.
Kozyrskyj, Anita L.
author_facet Rodriguez, Nicole
Tun, Hein M.
Field, Catherine J.
Mandhane, Piushkumar J.
Scott, James A.
Kozyrskyj, Anita L.
author_sort Rodriguez, Nicole
collection PubMed
description Depressive symptoms are common during pregnancy and are estimated to affect 7–20% of pregnant women, with higher prevalence found in those with a prior history of depression, in ethnic minorities, and those with increased exposure to stressful life events. Maternal depression often remains undiagnosed, and its symptoms can increase adverse health risks to the infant, including impaired cognitive development, behavioral problems, and higher susceptibility to physical illnesses. Accumulating research evidence supports the association between maternal physical health elements to infant gut health, including factors such as mode of delivery, medication, feeding status, and antibiotic use. However, specific maternal prenatal psychosocial factors and their effect on infant gut microbiota and immunity remains an area that is not well understood. This article reviews the literature and supplements it with new findings to show that prenatal depression alters: (i) gut microbial composition in partially and fully formula-fed infants at 3–4 months of age, and (ii) gut immunity (i.e., secretory Immunoglobulin A) in all infants independent of breastfeeding status. Understanding the implications of maternal depression on the infant gut microbiome is important to enhance both maternal and child health and to better inform disease outcomes and management.
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spelling pubmed-83632452021-08-14 Prenatal Depression, Breastfeeding, and Infant Gut Microbiota Rodriguez, Nicole Tun, Hein M. Field, Catherine J. Mandhane, Piushkumar J. Scott, James A. Kozyrskyj, Anita L. Front Microbiol Microbiology Depressive symptoms are common during pregnancy and are estimated to affect 7–20% of pregnant women, with higher prevalence found in those with a prior history of depression, in ethnic minorities, and those with increased exposure to stressful life events. Maternal depression often remains undiagnosed, and its symptoms can increase adverse health risks to the infant, including impaired cognitive development, behavioral problems, and higher susceptibility to physical illnesses. Accumulating research evidence supports the association between maternal physical health elements to infant gut health, including factors such as mode of delivery, medication, feeding status, and antibiotic use. However, specific maternal prenatal psychosocial factors and their effect on infant gut microbiota and immunity remains an area that is not well understood. This article reviews the literature and supplements it with new findings to show that prenatal depression alters: (i) gut microbial composition in partially and fully formula-fed infants at 3–4 months of age, and (ii) gut immunity (i.e., secretory Immunoglobulin A) in all infants independent of breastfeeding status. Understanding the implications of maternal depression on the infant gut microbiome is important to enhance both maternal and child health and to better inform disease outcomes and management. Frontiers Media S.A. 2021-07-30 /pmc/articles/PMC8363245/ /pubmed/34394021 http://dx.doi.org/10.3389/fmicb.2021.664257 Text en Copyright © 2021 Rodriguez, Tun, Field, Mandhane, Scott and Kozyrskyj. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Rodriguez, Nicole
Tun, Hein M.
Field, Catherine J.
Mandhane, Piushkumar J.
Scott, James A.
Kozyrskyj, Anita L.
Prenatal Depression, Breastfeeding, and Infant Gut Microbiota
title Prenatal Depression, Breastfeeding, and Infant Gut Microbiota
title_full Prenatal Depression, Breastfeeding, and Infant Gut Microbiota
title_fullStr Prenatal Depression, Breastfeeding, and Infant Gut Microbiota
title_full_unstemmed Prenatal Depression, Breastfeeding, and Infant Gut Microbiota
title_short Prenatal Depression, Breastfeeding, and Infant Gut Microbiota
title_sort prenatal depression, breastfeeding, and infant gut microbiota
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363245/
https://www.ncbi.nlm.nih.gov/pubmed/34394021
http://dx.doi.org/10.3389/fmicb.2021.664257
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