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New Perspectives on Desensitization in the Current Era - An Overview

Blood group and tissue incompatibilities remain significant barriers to achieving transplantation. Although no patient should be labeled “un-transplantable” due to blood group or tissue incompatibility, all candidates should be provided with individualized and realistic counseling regarding their an...

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Autores principales: Kumar, Vineeta, Locke, Jayme E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363260/
https://www.ncbi.nlm.nih.gov/pubmed/34394089
http://dx.doi.org/10.3389/fimmu.2021.696467
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author Kumar, Vineeta
Locke, Jayme E.
author_facet Kumar, Vineeta
Locke, Jayme E.
author_sort Kumar, Vineeta
collection PubMed
description Blood group and tissue incompatibilities remain significant barriers to achieving transplantation. Although no patient should be labeled “un-transplantable” due to blood group or tissue incompatibility, all candidates should be provided with individualized and realistic counseling regarding their anticipated wait times for deceased donor or kidney paired donation matching, with early referral to expert centers for desensitization when needed. Vital is the careful selection of patients whose health status is such that desensitizing treatment is less likely to cause serious harm and whose anti-HLA antibody status is such that treatment is likely to accomplish the goal of increasing organ offers with an acceptable final crossmatch. Exciting new developments have re-energized the interest and scope of desensitization in the times ahead.
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spelling pubmed-83632602021-08-14 New Perspectives on Desensitization in the Current Era - An Overview Kumar, Vineeta Locke, Jayme E. Front Immunol Immunology Blood group and tissue incompatibilities remain significant barriers to achieving transplantation. Although no patient should be labeled “un-transplantable” due to blood group or tissue incompatibility, all candidates should be provided with individualized and realistic counseling regarding their anticipated wait times for deceased donor or kidney paired donation matching, with early referral to expert centers for desensitization when needed. Vital is the careful selection of patients whose health status is such that desensitizing treatment is less likely to cause serious harm and whose anti-HLA antibody status is such that treatment is likely to accomplish the goal of increasing organ offers with an acceptable final crossmatch. Exciting new developments have re-energized the interest and scope of desensitization in the times ahead. Frontiers Media S.A. 2021-07-30 /pmc/articles/PMC8363260/ /pubmed/34394089 http://dx.doi.org/10.3389/fimmu.2021.696467 Text en Copyright © 2021 Kumar and Locke https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kumar, Vineeta
Locke, Jayme E.
New Perspectives on Desensitization in the Current Era - An Overview
title New Perspectives on Desensitization in the Current Era - An Overview
title_full New Perspectives on Desensitization in the Current Era - An Overview
title_fullStr New Perspectives on Desensitization in the Current Era - An Overview
title_full_unstemmed New Perspectives on Desensitization in the Current Era - An Overview
title_short New Perspectives on Desensitization in the Current Era - An Overview
title_sort new perspectives on desensitization in the current era - an overview
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363260/
https://www.ncbi.nlm.nih.gov/pubmed/34394089
http://dx.doi.org/10.3389/fimmu.2021.696467
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