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Drug Design Strategies for the Treatment of Viral Disease. Plant Phenolic Compounds and Their Derivatives

The coronavirus pandemic (SARS CoV-2) that has existed for over a year, constantly forces scientists to search for drugs against this virus. In silico research and selected experimental data have shown that compounds of natural origin such as phenolic acids and flavonoids have promising antiviral po...

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Autores principales: Kowalczyk, Monika, Golonko, Aleksandra, Świsłocka, Renata, Kalinowska, Monika, Parcheta, Monika, Swiergiel, Artur, Lewandowski, Włodzimierz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363300/
https://www.ncbi.nlm.nih.gov/pubmed/34393787
http://dx.doi.org/10.3389/fphar.2021.709104
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author Kowalczyk, Monika
Golonko, Aleksandra
Świsłocka, Renata
Kalinowska, Monika
Parcheta, Monika
Swiergiel, Artur
Lewandowski, Włodzimierz
author_facet Kowalczyk, Monika
Golonko, Aleksandra
Świsłocka, Renata
Kalinowska, Monika
Parcheta, Monika
Swiergiel, Artur
Lewandowski, Włodzimierz
author_sort Kowalczyk, Monika
collection PubMed
description The coronavirus pandemic (SARS CoV-2) that has existed for over a year, constantly forces scientists to search for drugs against this virus. In silico research and selected experimental data have shown that compounds of natural origin such as phenolic acids and flavonoids have promising antiviral potential. Phenolic compounds inhibit multiplication of viruses at various stages of the viral life cycle, e.g., attachment (disturbance of the interaction between cellular and viral receptors), penetration (inhibition of viral pseudo-particle fusion to the host membrane), replication (inhibition of integrase and 3C-like protease), assembly and maturation (inhibition of microsomal triglyceride transfer protein (MTP) activity hydrolysis) and release (inhibition of secretion of apolipoprotein B (apoB) from infected cells). Phenolic compounds also indirectly influence on the viral life cycle by affecting the host cell’s biochemical processes that viruses use for their own benefit. Phenolic compounds may inhibit the proteasomes and cellular deubiquitinating activity that causes an increase in the ubiquitinated proteins level in host cells. This, in turn, contributes to the lowering the available ubiquitin molecules that viruses could use for their own replication. One of the drug design strategy for the treatment of viral diseases may be an enhancement of the antiviral properties of phenolic compounds by metal complexation. Many studies have shown that the presence of a metal ion in the structure can significantly affect the affinity of the compound to key structural elements of the SARS CoV-2, such as M(pro) protease, RNA-dependent RNA polymerase (RdRp) and spike protein. We believe that in the era of coronavirus pandemic, it is necessary to reconsider the search for therapeutics among well-known compounds of plant origin and their metal complexes.
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spelling pubmed-83633002021-08-14 Drug Design Strategies for the Treatment of Viral Disease. Plant Phenolic Compounds and Their Derivatives Kowalczyk, Monika Golonko, Aleksandra Świsłocka, Renata Kalinowska, Monika Parcheta, Monika Swiergiel, Artur Lewandowski, Włodzimierz Front Pharmacol Pharmacology The coronavirus pandemic (SARS CoV-2) that has existed for over a year, constantly forces scientists to search for drugs against this virus. In silico research and selected experimental data have shown that compounds of natural origin such as phenolic acids and flavonoids have promising antiviral potential. Phenolic compounds inhibit multiplication of viruses at various stages of the viral life cycle, e.g., attachment (disturbance of the interaction between cellular and viral receptors), penetration (inhibition of viral pseudo-particle fusion to the host membrane), replication (inhibition of integrase and 3C-like protease), assembly and maturation (inhibition of microsomal triglyceride transfer protein (MTP) activity hydrolysis) and release (inhibition of secretion of apolipoprotein B (apoB) from infected cells). Phenolic compounds also indirectly influence on the viral life cycle by affecting the host cell’s biochemical processes that viruses use for their own benefit. Phenolic compounds may inhibit the proteasomes and cellular deubiquitinating activity that causes an increase in the ubiquitinated proteins level in host cells. This, in turn, contributes to the lowering the available ubiquitin molecules that viruses could use for their own replication. One of the drug design strategy for the treatment of viral diseases may be an enhancement of the antiviral properties of phenolic compounds by metal complexation. Many studies have shown that the presence of a metal ion in the structure can significantly affect the affinity of the compound to key structural elements of the SARS CoV-2, such as M(pro) protease, RNA-dependent RNA polymerase (RdRp) and spike protein. We believe that in the era of coronavirus pandemic, it is necessary to reconsider the search for therapeutics among well-known compounds of plant origin and their metal complexes. Frontiers Media S.A. 2021-07-30 /pmc/articles/PMC8363300/ /pubmed/34393787 http://dx.doi.org/10.3389/fphar.2021.709104 Text en Copyright © 2021 Kowalczyk, Golonko, Świsłocka, Kalinowska, Parcheta, Swiergiel and Lewandowski. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Kowalczyk, Monika
Golonko, Aleksandra
Świsłocka, Renata
Kalinowska, Monika
Parcheta, Monika
Swiergiel, Artur
Lewandowski, Włodzimierz
Drug Design Strategies for the Treatment of Viral Disease. Plant Phenolic Compounds and Their Derivatives
title Drug Design Strategies for the Treatment of Viral Disease. Plant Phenolic Compounds and Their Derivatives
title_full Drug Design Strategies for the Treatment of Viral Disease. Plant Phenolic Compounds and Their Derivatives
title_fullStr Drug Design Strategies for the Treatment of Viral Disease. Plant Phenolic Compounds and Their Derivatives
title_full_unstemmed Drug Design Strategies for the Treatment of Viral Disease. Plant Phenolic Compounds and Their Derivatives
title_short Drug Design Strategies for the Treatment of Viral Disease. Plant Phenolic Compounds and Their Derivatives
title_sort drug design strategies for the treatment of viral disease. plant phenolic compounds and their derivatives
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363300/
https://www.ncbi.nlm.nih.gov/pubmed/34393787
http://dx.doi.org/10.3389/fphar.2021.709104
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