Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways

APOBEC3A is a cytidine deaminase driving mutagenesis in tumors. While APOBEC3A-induced mutations are common, APOBEC3A expression is rarely detected in cancer cells. This discrepancy suggests a tightly controlled process to regulate episodic APOBEC3A expression in tumors. In this study, we find that...

Descripción completa

Detalles Bibliográficos
Autores principales: Oh, Sunwoo, Bournique, Elodie, Bowen, Danae, Jalili, Pégah, Sanchez, Ambrocio, Ward, Ian, Dananberg, Alexandra, Manjunath, Lavanya, Tran, Genevieve P., Semler, Bert L., Maciejowski, John, Seldin, Marcus, Buisson, Rémi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363607/
https://www.ncbi.nlm.nih.gov/pubmed/34389714
http://dx.doi.org/10.1038/s41467-021-25203-4

Ejemplares similares

Ejemplares similares