The ERAP1 active site cannot productively access the N-terminus of antigenic peptide precursors stably bound onto MHC class I

Processing of N-terminally elongated antigenic peptide precursors by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) is a key step in antigen presentation and the adaptive immune response. Although ERAP1 can efficiently process long peptides in solution, it has been proposed that it can also process...

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Detalles Bibliográficos
Autores principales: Mavridis, George, Mpakali, Anastasia, Zoidakis, Jerome, Makridakis, Manousos, Vlahou, Antonia, Kaloumenou, Eleni, Ziotopoulou, Angeliki, Georgiadis, Dimitris, Papakyriakou, Athanasios, Stratikos, Efstratios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363620/
https://www.ncbi.nlm.nih.gov/pubmed/34389743
http://dx.doi.org/10.1038/s41598-021-95786-x

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