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Effect of Landiolol Hydrochloride on Hemodynamics in a Histamine-Induced Shock Model
BACKGROUND AND OBJECTIVE: Anaphylactic shock is a serious adverse drug reaction that can occur in response to contrast media used during coronary computed tomography angiography. The imaging quality of coronary computed tomography angiography is improved by β-blockers, which decrease heart rate. In...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363724/ https://www.ncbi.nlm.nih.gov/pubmed/34128200 http://dx.doi.org/10.1007/s40268-021-00354-3 |
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author | Hirano, Masaharu Okamura, Tatsuaki Nagano, Tetsuji Nonaka, Shigeyuki Shiroya, Tsutomu |
author_facet | Hirano, Masaharu Okamura, Tatsuaki Nagano, Tetsuji Nonaka, Shigeyuki Shiroya, Tsutomu |
author_sort | Hirano, Masaharu |
collection | PubMed |
description | BACKGROUND AND OBJECTIVE: Anaphylactic shock is a serious adverse drug reaction that can occur in response to contrast media used during coronary computed tomography angiography. The imaging quality of coronary computed tomography angiography is improved by β-blockers, which decrease heart rate. In this study, we sought to analyze anaphylactic shock treatment in patients receiving short-acting β1-blockers. METHODS: We examined the influence of epinephrine and glucagon on hemodynamics during β-blocker treatment, using a dog histamine shock model; the β1-blocker landiolol hydrochloride was used. The effects of these drugs were assessed by recording changes relative to established baselines. RESULTS: Histamine and landiolol decreased mean blood pressure. Histamine exerted no apparent effect on heart rate, whereas landiolol decreased heart rate. Further, landiolol reduced histamine-mediated increases in the force of cardiac contraction. Increasing the doses of epinephrine and glucagon ameliorated anaphylactic shock-induced deterioration in hemodynamic parameters in subjects receiving landiolol. CONCLUSIONS: In patients receiving landiolol for coronary computed tomography angiography, deterioration in hemodynamic parameters due to anaphylactic shock can be mitigated by increasing the doses of epinephrine and glucagon. Clinicians should thus prepare appropriate amounts of epinephrine and glucagon prior to coronary computed tomography angiography. |
format | Online Article Text |
id | pubmed-8363724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-83637242021-08-30 Effect of Landiolol Hydrochloride on Hemodynamics in a Histamine-Induced Shock Model Hirano, Masaharu Okamura, Tatsuaki Nagano, Tetsuji Nonaka, Shigeyuki Shiroya, Tsutomu Drugs R D Original Research Article BACKGROUND AND OBJECTIVE: Anaphylactic shock is a serious adverse drug reaction that can occur in response to contrast media used during coronary computed tomography angiography. The imaging quality of coronary computed tomography angiography is improved by β-blockers, which decrease heart rate. In this study, we sought to analyze anaphylactic shock treatment in patients receiving short-acting β1-blockers. METHODS: We examined the influence of epinephrine and glucagon on hemodynamics during β-blocker treatment, using a dog histamine shock model; the β1-blocker landiolol hydrochloride was used. The effects of these drugs were assessed by recording changes relative to established baselines. RESULTS: Histamine and landiolol decreased mean blood pressure. Histamine exerted no apparent effect on heart rate, whereas landiolol decreased heart rate. Further, landiolol reduced histamine-mediated increases in the force of cardiac contraction. Increasing the doses of epinephrine and glucagon ameliorated anaphylactic shock-induced deterioration in hemodynamic parameters in subjects receiving landiolol. CONCLUSIONS: In patients receiving landiolol for coronary computed tomography angiography, deterioration in hemodynamic parameters due to anaphylactic shock can be mitigated by increasing the doses of epinephrine and glucagon. Clinicians should thus prepare appropriate amounts of epinephrine and glucagon prior to coronary computed tomography angiography. Springer International Publishing 2021-06-14 2021-09 /pmc/articles/PMC8363724/ /pubmed/34128200 http://dx.doi.org/10.1007/s40268-021-00354-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Original Research Article Hirano, Masaharu Okamura, Tatsuaki Nagano, Tetsuji Nonaka, Shigeyuki Shiroya, Tsutomu Effect of Landiolol Hydrochloride on Hemodynamics in a Histamine-Induced Shock Model |
title | Effect of Landiolol Hydrochloride on Hemodynamics in a Histamine-Induced Shock Model |
title_full | Effect of Landiolol Hydrochloride on Hemodynamics in a Histamine-Induced Shock Model |
title_fullStr | Effect of Landiolol Hydrochloride on Hemodynamics in a Histamine-Induced Shock Model |
title_full_unstemmed | Effect of Landiolol Hydrochloride on Hemodynamics in a Histamine-Induced Shock Model |
title_short | Effect of Landiolol Hydrochloride on Hemodynamics in a Histamine-Induced Shock Model |
title_sort | effect of landiolol hydrochloride on hemodynamics in a histamine-induced shock model |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363724/ https://www.ncbi.nlm.nih.gov/pubmed/34128200 http://dx.doi.org/10.1007/s40268-021-00354-3 |
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