Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior

Epitranscriptomic mechanisms linking tRNA function and the brain proteome to cognition and complex behaviors are not well described. Here, we report bi-directional changes in depression-related behaviors after genetic disruption of neuronal tRNA cytosine methylation, including conditional ablation a...

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Detalles Bibliográficos
Autores principales: Blaze, J., Navickas, A., Phillips, H. L., Heissel, S., Plaza-Jennings, A., Miglani, S., Asgharian, H., Foo, M., Katanski, C. D., Watkins, C. P., Pennington, Z. T., Javidfar, B., Espeso-Gil, S., Rostandy, B., Alwaseem, H., Hahn, C. G., Molina, H., Cai, D. J., Pan, T., Yao, W. D., Goodarzi, H., Haghighi, F., Akbarian, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363735/
https://www.ncbi.nlm.nih.gov/pubmed/34389722
http://dx.doi.org/10.1038/s41467-021-24969-x

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