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Strong association of type 2 diabetes with degenerative lumbar spine disorders
Tantalizing connections between type 2 diabetes and degenerative lumbar spine disorders have become increasingly evident. However, the association of type 2 diabetes with degenerative lumbar spine disorders remains unclear. We sought to clarify the association between type 2 diabetes and lumbar spin...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363740/ https://www.ncbi.nlm.nih.gov/pubmed/34389750 http://dx.doi.org/10.1038/s41598-021-95626-y |
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author | Park, Chul-Hyun Min, Kyoung-Bok Min, Jin-Young Kim, Du Hwan Seo, Kyung Mook Kim, Don-Kyu |
author_facet | Park, Chul-Hyun Min, Kyoung-Bok Min, Jin-Young Kim, Du Hwan Seo, Kyung Mook Kim, Don-Kyu |
author_sort | Park, Chul-Hyun |
collection | PubMed |
description | Tantalizing connections between type 2 diabetes and degenerative lumbar spine disorders have become increasingly evident. However, the association of type 2 diabetes with degenerative lumbar spine disorders remains unclear. We sought to clarify the association between type 2 diabetes and lumbar spine disorders using nationwide data in Korea. Furthermore, we explored the association of diabetes with the prevalence of spinal procedures. The data in this study was obtained from Korean health claim database. Between 2016 and 2019, totals of 479,680 diabetes and 479,680 age- and sex-matched control subjects were enrolled. Patients with diabetes had more likely to have degenerative lumbar spine disorders and spinal procedures than controls. Using multivariate-adjusted analysis, patients with diabetes were at increased risk of being concomitantly affected by lumbar disc disorder [adjusted odds ratio 1.11 (95% confidence interval 1.10–1.12)], lumbar spondylotic radiculopathy [1.12 (1.11–1.13)], spondylolisthesis [1.05 (1.02–1.08)] and spinal stenosis [1.16 (1.15–1.18)], compared to controls. Furthermore, diabetic patients had an increased risk of undergoing lumbar spinal injection [1.13 (1.12–1.14)], laminectomy [1.19 (1.15–1.23)], and fusion surgery [1.35 (1.29–1.42)]. We demonstrated that type 2 diabetes was significantly associated with lumbar spine disorders and frequent spinal procedures. Our results suggest diabetes as a predisposing factor for lumbar spine disorders. |
format | Online Article Text |
id | pubmed-8363740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-83637402021-08-17 Strong association of type 2 diabetes with degenerative lumbar spine disorders Park, Chul-Hyun Min, Kyoung-Bok Min, Jin-Young Kim, Du Hwan Seo, Kyung Mook Kim, Don-Kyu Sci Rep Article Tantalizing connections between type 2 diabetes and degenerative lumbar spine disorders have become increasingly evident. However, the association of type 2 diabetes with degenerative lumbar spine disorders remains unclear. We sought to clarify the association between type 2 diabetes and lumbar spine disorders using nationwide data in Korea. Furthermore, we explored the association of diabetes with the prevalence of spinal procedures. The data in this study was obtained from Korean health claim database. Between 2016 and 2019, totals of 479,680 diabetes and 479,680 age- and sex-matched control subjects were enrolled. Patients with diabetes had more likely to have degenerative lumbar spine disorders and spinal procedures than controls. Using multivariate-adjusted analysis, patients with diabetes were at increased risk of being concomitantly affected by lumbar disc disorder [adjusted odds ratio 1.11 (95% confidence interval 1.10–1.12)], lumbar spondylotic radiculopathy [1.12 (1.11–1.13)], spondylolisthesis [1.05 (1.02–1.08)] and spinal stenosis [1.16 (1.15–1.18)], compared to controls. Furthermore, diabetic patients had an increased risk of undergoing lumbar spinal injection [1.13 (1.12–1.14)], laminectomy [1.19 (1.15–1.23)], and fusion surgery [1.35 (1.29–1.42)]. We demonstrated that type 2 diabetes was significantly associated with lumbar spine disorders and frequent spinal procedures. Our results suggest diabetes as a predisposing factor for lumbar spine disorders. Nature Publishing Group UK 2021-08-13 /pmc/articles/PMC8363740/ /pubmed/34389750 http://dx.doi.org/10.1038/s41598-021-95626-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Park, Chul-Hyun Min, Kyoung-Bok Min, Jin-Young Kim, Du Hwan Seo, Kyung Mook Kim, Don-Kyu Strong association of type 2 diabetes with degenerative lumbar spine disorders |
title | Strong association of type 2 diabetes with degenerative lumbar spine disorders |
title_full | Strong association of type 2 diabetes with degenerative lumbar spine disorders |
title_fullStr | Strong association of type 2 diabetes with degenerative lumbar spine disorders |
title_full_unstemmed | Strong association of type 2 diabetes with degenerative lumbar spine disorders |
title_short | Strong association of type 2 diabetes with degenerative lumbar spine disorders |
title_sort | strong association of type 2 diabetes with degenerative lumbar spine disorders |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363740/ https://www.ncbi.nlm.nih.gov/pubmed/34389750 http://dx.doi.org/10.1038/s41598-021-95626-y |
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