RSPO3 is important for trabecular bone and fracture risk in mice and humans

With increasing age of the population, countries across the globe are facing a substantial increase in osteoporotic fractures. Genetic association signals for fractures have been reported at the RSPO3 locus, but the causal gene and the underlying mechanism are unknown. Here we show that the fracture...

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Detalles Bibliográficos
Autores principales: Nilsson, Karin H., Henning, Petra, El Shahawy, Maha, Nethander, Maria, Andersen, Thomas Levin, Ejersted, Charlotte, Wu, Jianyao, Gustafsson, Karin L., Koskela, Antti, Tuukkanen, Juha, Souza, Pedro P. C., Tuckermann, Jan, Lorentzon, Mattias, Ruud, Linda Engström, Lehtimäki, Terho, Tobias, Jon H., Zhou, Sirui, Lerner, Ulf H., Richards, J. Brent, Movérare-Skrtic, Sofia, Ohlsson, Claes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363747/
https://www.ncbi.nlm.nih.gov/pubmed/34389713
http://dx.doi.org/10.1038/s41467-021-25124-2

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