Cargando…

The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core

BAX is a pro-apoptotic member of the BCL-2 family, which regulates the balance between cellular life and death. During homeostasis, BAX predominantly resides in the cytosol as a latent monomer but, in response to stress, transforms into an oligomeric protein that permeabilizes the mitochondria, lead...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bloch, Noah B., Wales, Thomas E., Prew, Michelle S., Levy, Hannah R., Engen, John R., Walensky, Loren D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363748/ https://www.ncbi.nlm.nih.gov/pubmed/34389733 http://dx.doi.org/10.1038/s41467-021-25200-7

Ejemplares similares

Allosteric Sensitization of Pro-Apoptotic BAX
por: Pritz, Jonathan R., et al.
Publicado: (2017)

Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX
por: Cohen, Daniel T., et al.
Publicado: (2020)

Conformational control of Bax localization and apoptotic activity by Pro168
por: Schinzel, Anna, et al.
Publicado: (2004)

Conformational changes and protein stability of the pro-apoptotic protein Bax
por: Bleicken, Stephanie, et al.
Publicado: (2009)

A redox switch regulates the structure and function of anti-apoptotic BFL-1
por: Korshavn, Kyle J., et al.
Publicado: (2020)

Bioactive lipids and the control of Bax pro-apoptotic activity
por: Mignard, V, et al.
Publicado: (2014)

Allosteric Inhibition of Anti-Apoptotic MCL-1
por: Lee, Susan, et al.
Publicado: (2016)

BAX pro-apoptotic gene alterations in repeated pregnancy loss
por: Mohammad Seyedhassani, Seyed, et al.
Publicado: (2011)

Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency
por: Prew, Michelle S., et al.
Publicado: (2022)

Conformational Heterogeneity of Bax Helix 9 Dimer for Apoptotic Pore Formation
por: Liao, Chenyi, et al.
Publicado: (2016)

Pro-apoptotic Bax molecules densely populate the edges of membrane pores
por: Kuwana, Tomomi, et al.
Publicado: (2016)

Membrane insertion of the BAX core, but not latch domain, drives apoptotic pore formation
por: Flores-Romero, Hector, et al.
Publicado: (2017)

An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial␣membrane
por: Lv, Fujiao, et al.
Publicado: (2021)

Targeting a Helix-in-Groove Interaction Between E1 and E2 Blocks Ubiquitin Transfer
por: Cathcart, Ann M., et al.
Publicado: (2020)

Chlamydia trachomatis inhibits apoptosis in infected cells by targeting the pro-apoptotic proteins Bax and Bak
por: Waguia Kontchou, Collins, et al.
Publicado: (2022)

Integrin-Mediated Survival Signals Regulate the Apoptotic Function of Bax through Its Conformation and Subcellular Localization
por: Gilmore, Andrew P., et al.
Publicado: (2000)

Brain and Testicular Tumors in Mice with Progenitor Cells Lacking BAX and BAK
por: Katz, Samuel G., et al.
Publicado: (2012)

The Pro-Apoptotic Proteins, Bid and Bax, Cause a Limited Permeabilization of the Mitochondrial Outer Membrane That Is Enhanced by Cytosol
por: Kluck, Ruth M., et al.
Publicado: (1999)

Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis
por: Karlberg, M, et al.
Publicado: (2010)

Ablation of the Pro-Apoptotic Protein Bax Protects Mice from Glucocorticoid-Induced Bone Growth Impairment
por: Zaman, Farasat, et al.
Publicado: (2012)

The N-terminus and alpha-5, alpha-6 helices of the pro-apoptotic protein Bax, modulate functional interactions with the anti-apoptotic protein Bcl-x(L)
por: Parikh, Neha, et al.
Publicado: (2007)

Pro-apoptotic Bax mRNA expression: A novel predictor for systemic lupus erythematosus disease flare-up
por: Yousef, Rasha N, et al.
Publicado: (2022)

Reconstitution of the Anti-Apoptotic Bcl-2 Protein into Lipid Membranes and Biophysical Evidence for Its Detergent-Driven Association with the Pro-Apoptotic Bax Protein
por: Wallgren, Marcus, et al.
Publicado: (2013)

Design of Stapled Antimicrobial Peptides that Overcome Antibiotic Resistance and In Vivo Toxicity
por: Mourtada, Rida, et al.
Publicado: (2019)

TFIIS.h, a new target of p53, regulates transcription efficiency of pro-apoptotic bax gene
por: Liao, Jun-Ming, et al.
Publicado: (2016)

Expression of Apoptotic Markers Bcl-2 and Bax in the Vascular Wall
por: Klimentova, E.A., et al.
Publicado: (2021)

Cdk2 phosphorylation of Bcl-xL after stress converts it to a pro-apoptotic protein mimicking Bax/Bak
por: Megyesi, J, et al.
Publicado: (2016)

BAX Activation is Initiated at a Novel Interaction Site
por: Gavathiotis, Evripidis, et al.
Publicado: (2008)

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX
por: Powers, Marissa V, et al.
Publicado: (2013)

Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin
por: Charan, R A, et al.
Publicado: (2014)

BAX and SMAC regulate bistable properties of the apoptotic caspase system
por: McKenna, Stephanie, et al.
Publicado: (2021)

Charge Profile Analysis Reveals That Activation of Pro-apoptotic Regulators Bax and Bak Relies on Charge Transfer Mediated Allosteric Regulation
por: Ionescu, Crina-Maria, et al.
Publicado: (2012)

High‐resolution analysis of the conformational transition of pro‐apoptotic Bak at the lipid membrane
por: Sperl, Laura E, et al.
Publicado: (2021)

Effect of L-carnitine on the expression of the apoptotic genes Bcl-2 and Bax
por: Vardiyan, Reyhane, et al.
Publicado: (2020)

Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma
por: Guttà, Cristiano, et al.
Publicado: (2020)

Differential impact of BTK active site inhibitors on the conformational state of full-length BTK
por: Joseph, Raji E, et al.
Publicado: (2020)

Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs
por: Diepstraten, Sarah T., et al.
Publicado: (2023)

Apoptotic stress induces Bax-dependent, caspase-independent redistribution of LINC complex nesprins
por: Lindenboim, Liora, et al.
Publicado: (2020)

The apoptotic response in HCT116(BAX-/- )cancer cells becomes rapidly saturated with increasing expression of a GFP-BAX fusion protein
por: Semaan, Sheila J, et al.
Publicado: (2010)

A Discrete Class of Intergenic DNA Dictates Meiotic DNA Break Hotspots in Fission Yeast
por: Cromie, Gareth A, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_0hdvj672jn00qtjog035vv02il