Metabolome and proteome analyses reveal transcriptional misregulation in glycolysis of engineered E. coli

Synthetic metabolic pathways are a burden for engineered bacteria, but the underlying mechanisms often remain elusive. Here we show that the misregulated activity of the transcription factor Cra is responsible for the growth burden of glycerol overproducing E. coli. Glycerol production decreases the...

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Detalles Bibliográficos
Autores principales: Wang, Chun-Ying, Lempp, Martin, Farke, Niklas, Donati, Stefano, Glatter, Timo, Link, Hannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363753/
https://www.ncbi.nlm.nih.gov/pubmed/34389727
http://dx.doi.org/10.1038/s41467-021-25142-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363753/
https://www.ncbi.nlm.nih.gov/pubmed/34389727
http://dx.doi.org/10.1038/s41467-021-25142-0

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