A Cas12a-based CRISPR interference system for multigene regulation in mycobacteria

Mycobacteria are responsible for a heavy global disease burden, but their relative genetic intractability has long frustrated research efforts. The introduction of clustered regularly interspaced short palindromic repeats (CRISPR) interference (CRISPRi) has made gene repression in mycobacteria much...

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Detalles Bibliográficos
Autores principales: Fleck, Neil, Grundner, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363830/
https://www.ncbi.nlm.nih.gov/pubmed/34298016
http://dx.doi.org/10.1016/j.jbc.2021.100990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363830/
https://www.ncbi.nlm.nih.gov/pubmed/34298016
http://dx.doi.org/10.1016/j.jbc.2021.100990

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