Cargando…
A Cas12a-based CRISPR interference system for multigene regulation in mycobacteria
Mycobacteria are responsible for a heavy global disease burden, but their relative genetic intractability has long frustrated research efforts. The introduction of clustered regularly interspaced short palindromic repeats (CRISPR) interference (CRISPRi) has made gene repression in mycobacteria much...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363830/ https://www.ncbi.nlm.nih.gov/pubmed/34298016 http://dx.doi.org/10.1016/j.jbc.2021.100990 |